Does Improving Vagal Tone Increase Mitochondrial Bioenergetics

Status Completed

Clinical Trial Summary

This study evaluates the effect of auricular neurostimulation on mitochondrial bioenergetics and inflammation through vagal nerve modulation via non-invasive percutaneous electrical nerve field stimulator in children with functional gastrointestinal disorders.

Clinical Trial Description

In understanding the pathophysiology of pediatric functional gastrointestinal disorders (FGID), it has been documented that subjects have decreased vagal tone. Vagal tone in turn modulates mitochondrial bioenergetics and plays a role in anti inflammatory effects. Further defining these brain-body connections that underlie FGID's could help guide future treatment. The investigators postulate that a 4 week neuro-stimulation with an Electro Auricular Device that has already shown to increase vagal tone will produce an increase in mitochondrial bioenergetics and decrease in inflammatory markers in this patient group. ;

Study Design

Related Conditions & MeSH terms

Abdominal Pain
Digestive System Diseases
Dyspepsia
Functional Abdominal Pain Syndrome
Functional Gastrointestinal Disorders
Gastrointestinal Diseases
Irritable Bowel Syndrome
Syndrome

Clinical Trial Details

NCT number	NCT03931330
Study type	Interventional
Source	Medical College of Wisconsin
Contact
Status	Completed
Phase	N/A
Start date	February 6, 2019
Completion date	September 24, 2019

View Details

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