Clinical Trials Logo
  1. Home
  2. Invasive Fungal Infection
  3. NCT02510053

Pharmacokinetics and Pharmacodynamics of Caspofungin (Cancidas ®) and Drug Tolerance of Fungi to Patients With an Invasive Fungal Infection in the Intensive Care Unit

Invasive Fungal Infection Clinical Trial

Official title:
PK-PD of Caspofungin (Cancidas ®) and Drug Tolerance of Fungi to Patients With an Invasive Fungal Infection in the Intensive Care Unit

Clinical Trial Summary

To investigate pharmacokinetics(PK) and pharmacodynamics(PD) of Caspofungin in ICU patients after received a loading dose of 70mg followed by 50mg (35mg if Child-Pugh score is 7-9), 40 patients will be recruited. Blood samplings for PK analysis will be collected on day 4 in this study. Caspofungin plasma concentrations are measured by using solid phase extraction and reverse phase high-performance liquid chromatography. Safety analyses will be taken daily during the treatment of Caspofungin. Tests for drug tolerance of fungi and efficacy assessment (clinical and mycological responses) will be taken every 3 days by clinical and mycological tests.

Clinical Trial Description

n/a

Study Design

Allocation: Non-Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02510053
Study type Interventional
Source Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Contact
Status Enrolling by invitation
Phase N/A
Start date July 2014
View Details
See also
  Status Clinical Trial Phase
Completed NCT01888458 - Antifungal Prophylaxis With Micafungin After Cord Blood Allogeneic Stem Cell Transplantation (MycaCOORD) Phase 2
Completed NCT00412893 - Isavuconazole (BAL8557) for Primary Treatment of Invasive Aspergillosis Phase 3
Completed NCT03066011 - Registry of Patients Treated With Systemic Mold-Active Triazoles
Completed NCT04004078 - An Individualized Administration Research of Voriconazole Based on CYP2C19 Gene Polymorphism and TDM
Completed NCT01576653 - Prospective Clinical Evaluation of Beta-D-Glucan Assay in Blood and BAL N/A
Completed NCT01198236 - Efficacy of Itraconazole as Secondary Prophylaxis in Patients Undergoing Allogeneic Stem Cell Transplantation or Chemotherapy With Prior Invasive Fungal Infection Phase 4
Recruiting NCT06137690 - Factors on Therapeutic Drug Monitoring and Safety of Voriconazole in Critically Ill Elderly Patients
Completed NCT01783379 - Pharmacokinetics of Micafungin in Patients Intensive Care Unit
Completed NCT01533558 - Pharmacokinetics of Caspofungin (Cancidas ®) Given Intravenously as Therapy to Patients With an Invasive Fungal Infection in the Intensive Care Unit - a Search for Co-variates
Recruiting NCT03149562 - Association of Plasma Transfusions and Invasive Fungal Infection
Recruiting NCT04665037 - Posaconazole (MK-5592) Intravenous and Oral in Children (<2 Years) With Invasive Fungal Infection (MK-5592-127) Phase 2
Withdrawn NCT01185405 - Voriconazole Plasma Level in Intensive Care Unit (ICU) Patients N/A
Terminated NCT01148160 - Voriconazole Trough Plasma Levels : Genetic Polymorphism, Efficacy, Safety in Patients With Hematologic Malignancy N/A
Completed NCT00893555 - Pharmacologic Optimization of Voriconazole Phase 3
Unknown status NCT00460330 - Evaluate Three Methods for Diagnosis of Invasive Fungal Infection in Chinese Patients After HSCT N/A
Completed NCT02823132 - Study of the Level of a Protein Which Could Predict the Development of a Fungal Infection in Patients With Acute Leukemia N/A