Overall Diet Quality and Breast Cancer Risk

Invasive Breast Cancer Clinical Trial

Official title:

Diet Quality Scores and Risk of Incident Breast Cancer in Healthy Women

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03304171
• Other study ID #: 1998-453
• Status: Completed
• Phase: N/A
• First received: October 3, 2017
• Last updated: October 9, 2017
• Start date: October 1995
• Est. completion date: December 31, 2011

Study information

• Verified date: October 2017
• Source: University of California, Irvine
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The purpose of this study was to examine the relationship between indices of overall diet quality and incident breast cancer risk in a large prospective cohort of women.

Description:

This study examined the role of overall diet quality on the risk of developing invasive breast cancer among 96,959 women in the California Teachers Study, in which 4,826 women were diagnosed with breast cancer during follow-up (1995-2011). Participants' dietary habits were recorded at baseline (1995) using a 103-item Block95 Food Frequency Questionnaire to allow for the assessment of overall diet quality. Specifically, diet quality was characterized by the Alternate Mediterranean Diet (aMED), Alternative Healthy Eating Index-2010 (AHEI-2010), Dietary Approaches to Stop Hypertension (DASH), and Paleolithic Index scores. Associations between diet quality and the risk of developing breast cancer were examined using multivariate Cox proportional hazard regression models to provide hazard ratios and corresponding 95% confidence intervals.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 96959
• Est. completion date: December 31, 2011
• Est. primary completion date: December 31, 2011
• Gender: Female
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Participants with no history of cancer diagnosis prior to baseline.

• Participants with no history of myocardial infarction prior to baseline.

• Participants with no history of stroke prior to baseline.

• Participants with no history of diabetes prior to baseline.

• Participants who are not missing excessive dietary data.

• Participants with energy intake values at =1% and =99% of the population distribution.

Related Conditions & MeSH terms

• Breast Neoplasms
• Incident Breast Cancer
• Invasive Breast Cancer

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of California, Irvine

References & Publications (1)

Bernstein L, Allen M, Anton-Culver H, Deapen D, Horn-Ross PL, Peel D, Pinder R, Reynolds P, Sullivan-Halley J, West D, Wright W, Ziogas A, Ross RK. High breast cancer incidence rates among California teachers: results from the California Teachers Study (United States). Cancer Causes Control. 2002 Sep;13(7):625-35. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Incident Invasive Breast Cancer	All incident cancer cases were identified through linkage with the California Cancer Registry (CCR) records, which is a population-based cancer registry for California residents.	1995-2011

External Links

•   California Teacher Study Homepage