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Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III — CLEAR III  

Intraventricular Hemorrhage Clinical Trial

Official title:
Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III

Clinical Trial Summary

The overall objective of this Phase III clinical trial is to obtain information from a population of 500 ICH subjects with intraventricular hemorrhage (IVH), representative of current clinical practice and national demographics of ICH regarding the benefit (or lack thereof) of IVH clot removal on subject function as measured by modified Rankin Scale (mRS). This application requests funding for five years to initiate a Phase III randomized clinical trial (RCT) testing the benefit of clot removal for intraventricular hemorrhage. The investigators propose to compare extraventricular drainage (EVD) use plus recombinant tissue plasminogen activator (rt-PA; Alteplase; Genentech, Inc., San Francisco, CA) with EVD+ placebo in the management and treatment of subjects with small intracerebral hemorrhage (ICH) and large intraventricular hemorrhage (IVH defined as ICH < 30 cc and obstruction of the 3rd or 4th ventricles by intraventricular blood clot).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00784134
Study type Interventional
Source Johns Hopkins University
Contact
Status Completed
Phase Phase 3
Start date July 2009
Completion date January 2016
View Details
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