Tranexamic Acid Versus Epinephrine During Exploratory Tympanotomy

Status Completed

Clinical Trial Summary

Exploratory tympanotomy is surgical access to the middle ear, made for diagnosis and management of unexplained conductive hearing loss, performed under an oto-microscope across the external auditory canal after tympanic membrane elevation to explore the middle ear structures

Clinical Trial Description

Epinephrine is a vasoconstrictor searched intensively for ptimization of the surgical field during microscopic ear and sinus surgeries with controversial results given the possible cardiovascular complication in case of systemic absorption,especially in vulnerable cardiac patients.Tranexamic acid (TXA) as an antifibrinolytic medication is used to treat or prevent excessive bleeding in significant trauma, surgery, tooth removal, or nasal bleeding, discovered by Japanese researchers. TXA, given either oral or intravenous, is a derivative of lysine amino acid; it acts reversibly on the lysine binding sites to block it on the plasminogen molecules. TXA consequently hinders the stimulation of plasminogen competitively, thus reduces its conversion into plasmin. Plasminogen is the enzyme that leads to the degradation of a fibrin clot, fibrinogen, and other plasma proteins, such as factors V and VIII. More than 95% of TXA intravenous administered dose eliminated unchanged through the urinary system. Twenty-four hours after intravenous administration of TXA has demonstrated accumulative excretion of approximately 90%, whereas only 3% is bound to plasminogen. TXA is minimally excreted in breast milk while it can freely cross the blood brain barrier and the placenta . ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04188184
Study type	Interventional
Source	Assiut University
Contact
Status	Completed
Phase	N/A
Start date	December 4, 2019
Completion date	April 10, 2020

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05900037` - GATT-Patch Versus SURGICEL® Original in Minimally Invasive Liver and Gallbladder Surgery	N/A
Recruiting	`NCT04609410` - Bleeding in Laparoscopic Liver Surgery	N/A
Terminated	`NCT01458561` - Adjunctive Application of BioFoam Surgical Matrix in Liver Surgery	Phase 3
Completed	`NCT04168879` - Sphenopalatine Ganglion Block for Nasal Surery	N/A
Completed	`NCT01656759` - Use of a Novel Fibrin Sealant in Total Knee Arthroplasty	Phase 2/Phase 3
Completed	`NCT01651806` - Weighted Versus Uniform Dose of Tranexamic Acid in Patients Undergoing Primary, Knee Arthroplasty	Phase 2/Phase 3
Completed	`NCT05867342` - Effects of Adrenaline Infiltration on Surgical Field of View in Endoscopic Sinus Surgery	Phase 4
Not yet recruiting	`NCT05841251` - Phenylephrine Versus Tranexamic Acid to Control Bleeding in Patients Undergoing Inferior Turbinoplasty by Coblation	N/A
Active, not recruiting	`NCT01539057` - The Efficacy of the Administration of Fibrinogen in Liver Transplantation	Phase 3
Completed	`NCT03820206` - The Value of Tranxemic Acid to Reduce Intraoperative Blood Loss During Elective Cesarean Sections in High Risk Women	N/A
Completed	`NCT01891461` - Study to Compare the Addition of Floseal to Our Standard of Care to Control Post Operative Bleeding in TKR	Phase 4
Completed	`NCT03047070` - Lidocaine in ERAS for FESS	Phase 2
Recruiting	`NCT04697498` - Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations	N/A
Recruiting	`NCT05385952` - GATT-Patch Versus TachoSil in Liver Surgery	N/A
Completed	`NCT02229292` - Prevention of Intraoperative Bleeding and Postoperative Swelling in Orthognathic Surgery Through the Use of Tranexamic Acid	Phase 4
Not yet recruiting	`NCT06264596` - Epinephrine in Irrigation Fluid for Visualization During Ankle Surgery	Phase 3
Recruiting	`NCT03112135` - Effect of Topical and Systemic Tranexemic Acid on Bleeding During Ear Exploration Surgery	Phase 2