Effect of Raised End-Tidal pCo2 on Choroidal Volume

Status Recruiting

Clinical Trial Summary

This study is to investigate the relationship between arterial carbon dioxide (CO2) concentration and vitreous pressure on the choroidal volume by integrated intraoperative OCT imaging under eye exams under anesthesia.

Clinical Trial Description

Children with normal eyes undergoing an exam under anesthesia or a non-intraocular eye procedure will have one eye examined after research consent is taken. Children have very elastic ocular tissues. When they are having an intraocular procedure positive vitreous pressure can cause the iris to prolapse out of the eye and this can cause intraoperative and postoperative complications. The causes of the positive vitreous pressure have been speculated to be due to an increase in choroidal volume. The Choroid is a layer of blood vessels sitting between the sclera and the retina. Ocular Coherence Tomography (OCT) is an imaging tool that allows an optical section of the retina, choroid and sclera to be examined. The subfoveal choroidal thickness has been shown to be a consistent area that can be measured with reliability that the anatomical site of measurement is consistent. By varying the end tidal CO2 the thickness of the choroid will be measured and at the same time the intraocular pressure taken using a pneumatonometer. The OCT is integrated into the operating microscope and is used to take a scan of the fovea. Three scans will be taken after 5minutes of the particular end tidal pCO2. In order to ensure the choroidal thickness is not being influenced by the axial length of the eye, the axial length will be measured using an ultrasound probe at the beginning of the measurements just once. In order to ensure that the position of the head and body is not influencing the choroidal thickness a spirit level will be used to ensure a flat operating bed at the beginning of the measurements. ;

Study Design

Related Conditions & MeSH terms

Intraocular Pressure

Clinical Trial Details

NCT number	NCT06275308
Study type	Interventional
Source	University of Pittsburgh
Contact	Amy Monroe, MPH, MBA
Phone	412-623-6382
Email	monroeal@upmc.edu
Status	Recruiting
Phase	N/A
Start date	February 27, 2023
Completion date	February 27, 2025

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03494257` - Effect of Fixed Brinzolamide-brimonidine Combination on Intraocular Pressure After Phacoemulsification	N/A
Completed	`NCT03016234` - IOP Changes With Different Anesthetic Agents During Laparoscopic Colorectal Surgery	N/A
Completed	`NCT04863209` - Effect of Osteopathic Techiniques on Intraocular Pressure	N/A
Completed	`NCT03139708` - The Effect of Brimonidine on Intraocular Pressure When Dilating Routine Patients	Phase 1
Completed	`NCT02646033` - Quantitative Rise in Intraocular Pressure in Steep Trendelenburg Position
Recruiting	`NCT02697825` - Intraocular Pressure Versus Optic Nerve Sheath Diameter	N/A
Completed	`NCT02985567` - An Observational Study of the Use of Chloral Hydrate for Ophthalmic Procedures in Children	N/A
Withdrawn	`NCT00837226` - Effects of Weight Loss From Bariatric Surgery on Intraocular Pressure (IOP)	N/A
Completed	`NCT02136589` - Effect of NSAID on Travoprost-induced Conjunctival Hyperemia and IOP Reduction in Normal Eyes	Phase 4
Completed	`NCT03123614` - Loteprednol vs. Prednisolone and Fluorometholone	Phase 4
Completed	`NCT05763056` - Effects of Intubation on Intra-ocular Pressure and Optic Nerve Sheath Diameter	N/A
Completed	`NCT03359200` - Analysis of the Microbiota in Goldmann Applanation Tonometers at a Reference Service in Goiânia	N/A
Withdrawn	`NCT02558309` - Optic Nerve Head Quantification While Reducing Elevated Intracranial Pressure	N/A
Completed	`NCT02816905` - Ocular-hypertensive Response to Topical Steroids in Children After Bilateral Strabismus Surgery	Phase 4
Completed	`NCT01786954` - iCare vs Tonopen vs Goldmann Applanation Post-vitrectomy Surgery	N/A
Completed	`NCT00552019` - Intraocular Pressure (IOP) Assessed by Dynamic Contour Tonometer (DCT) and Goldman Applanation Tonometry (GAT)	N/A
Completed	`NCT00428740` - Long-Term IOP Fluctuation and VF Progression After Triple Procedure	N/A
Completed	`NCT04360369` - Comparison of Intraocular Pressure Measurements Between Reichert Tono-Vera Tonometer and Goldmann Tonometry	N/A
Completed	`NCT04521140` - Assessing eFficacy and Safety of DEXTENZA 0.4 mg inseRt, Following Corneal Transplant Surgery	Phase 4
Completed	`NCT05167773` - Clinical Study of the Topcon Tonometer TRK-3