Intranasal Bupivacaine Clinical Trial
Official title:
Effects of Intranasal Injection of Dexmedetomidine Plus Bupivacaine on Anesthesia & Analgesia in Septoplasty Surgeries
Pain is particularly common after nasal surgery, especially when bone manipulation and periosteal irritation are involved. Appropriate pain control is an important consideration in the post-surgical management of patients.
Multiple researches and clinical observations suggest that pain reduction can be achieved in
nasal surgery by using local anesthesia.The combination of local anesthetic infiltration,
directly in the surgical field, with general anesthesia provides beneficial analgesic effects
by blocking nociceptive pathways, and there by it reduces the need for systemic analgesics.
The use of α-2 Adrenergic receptor (adrenoceptor) agonists in anesthesia were the focus of
interest for their sedative, analgesic, and perioperative sympatholytic and cardiovascular
stabilizing effects with reduced anesthetic requirements. α-2 agonists, inhibit substance P
release in the nociceptive pathway at the level of the dorsal root neuron; in addition, α-2
adrenergic receptors located at nerve endings may have a role in the analgesic effect of the
drug by preventing norepinephrine release.
In this study, the combined effects of dexmedetomidine with bupivacaine as local anesthetics
vs bupivacaine, will be investigated in septoplasty to determine the need for rescue drugs as
propanlol and nitroglycerine, as hypotensive agents,for bloodless surgical field and optimal
procedure for pain control
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