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Intracranial Hypertension clinical trials

View clinical trials related to Intracranial Hypertension.

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NCT ID: NCT04224532 Completed - Pneumoperitoneum Clinical Trials

The Effect of Pneumoperitoneum Timing on Intracranial Pressure in Laparoscopy

Start date: January 8, 2020
Phase: N/A
Study type: Interventional

Reverse Trendelenburg position has been shown to slightly reduce the intracranial pressure associated with pneumoperitoneum. However, there are no studies on the effect of the timing of reverse Trendelenburg position on intracranial pressure. This study will monitor the effect of reverse Trendelenburg position before or after pneumoperitoneum on intracranial pressure and regional cerebral oxygen saturation.

NCT ID: NCT04211064 Not yet recruiting - Clinical trials for Intracranial Hypertension

Comparison of the Effects of Deep and Moderate Neuromuscular Blockade on Optic Nerve Sheath Diameter

MBLONDE
Start date: September 2021
Phase: N/A
Study type: Interventional

Increased intracranial pressure (IICP) is a common problem in traumatic brain injuries and many medical diseases. Early recognition of IICP can save lives. Several invasive and non-invasive methods have been described for IICP diagnosis. In recent years, ultrasonographic measurement of optic nerve sheath diameter (ONSD) has become a popular method due to its high sensitivity and specificity for IICP estimation. Studies have shown that ONSD's ultrasonographic measurement correlates with the IICP and can detect intracranial hypertension. The ONSD measurement has advantages such as being easily applied by the clinician at the bedside, being non-invasive, providing immediate results, reproducibility and low cost. It is known that artificial carbon dioxide pneumoperitoneum created in laparoscopic surgeries increases intracranial pressure.However, it is not easy to estimate the degree of changes in ICP during laparoscopic surgery under general anesthesia. In the literature, there are many studies on the sonographic measurement of optic nerve sheath diameter to evaluate the effects of trendelenburg position on intracranial pressure with the use of different anesthetic drugs in laparoscopic surgeries. In addition, there are studies reporting that deep neuromuscular blockade in laparoscopic surgeries increases surgical vision and decreases analgesic requirement in postoperative period. The relationship between neuromuscular block level and intracranial pressure is not clear. From this point of view, the investigators would like to evaluate the effect of moderate and deep neuromuscular block level on intracranial pressure by sonographic measurement of optic nerve sheath diameter in laparoscopic cholecystectomy operations performed with standard pressure artificial carbon dioxide pneumoperitoneum.

NCT ID: NCT04207229 Completed - Hydrocephalus Clinical Trials

CERTAS Programmable Valve Registry

CERTAS
Start date: November 21, 2019
Phase:
Study type: Observational [Patient Registry]

Post-Market Clinical Follow-up Registry of Patients with CODMAN CERTAS Plus Programmable Valves.

NCT ID: NCT04188353 Completed - Clinical trials for Raised Intracranial Pressure

Effect of Intravenous Administration of Mannitol on ONSD in Patients With Raised ICP

Start date: February 24, 2019
Phase:
Study type: Observational

Osmotherapy with mannitol has been a common practice in patients with raised ICP. Monitoring its effect on ICP can be performed invasively and non-invasively. Due to a validated correlation between invasive ICP monitoring and ONSD measurement, it can be a tool to monitor acute and long term effects of osmotherapy non-invasively on ICP. This study examines the acute changes in sonographically measured ONSD brought about by the administration of mannitol. This can correlate with the changes in ICP in such patients and can be utilized as a tool for decision making/ point-of-care utility.

NCT ID: NCT04115553 Recruiting - Clinical trials for Intracranial Hypertension

Assessment of Venous Drainage in Idiopathic Intracranial Hypertension

HYPERPIC
Start date: February 19, 2020
Phase: N/A
Study type: Interventional

Intracranial hypertension (IIH) is a disorder producing a syndrome of increased intracranial pressure secondary to a compressive intracranial lesion or said to be idiopathic. The most common symptoms are headaches, blindness, pulsatile tinnitus or papillary edema. There are many options for the treatment of IIH, especially neurosurgery (derivation of cerebrospinal fluid or stent placement). Currently, idiopathic IIH has no clear etiology but the hypothesis of sino-venous insufficiency is more and more recognized. The assumption of venous insufficiency has not been demonstrated so far. Therefore the investigators propose to demonstrate that cerebral venous drainage pathways are altered in adult patients with idiopathic intracranial hypertension in comparison to healthy individuals having normal circulation. Assessment will be performed using Magnetic Resonance Imaging which is part of the patient care.

NCT ID: NCT04046523 Recruiting - Clinical trials for Intracranial Pressure Increase

Non-Invasive and Non-Contact Intracranial Pressure Waveform Recording Using Dynamic Video Ophthalmoscopy

ICP Waveform
Start date: August 31, 2019
Phase: N/A
Study type: Interventional

This study will test the use of video ophthalmoscope to provide information about intracranial pressure without the use of invasive methods, anesthesia or contact with the eye.

NCT ID: NCT04032379 Recruiting - Clinical trials for Benign Intracranial Hypertension

Diagnostic and Prognostic Biomarkers of Idiopathic Intracranial Hypertension

Start date: February 14, 2018
Phase:
Study type: Observational [Patient Registry]

Idiopathic intracranial hypertension (IIH) is a condition of unknown etiology, primarily affecting overweight females of childbearing age. Typically, patients experience headache and visual symptoms due to increased intracranial pressure (ICP) and papilledema. The diagnosis is difficult, and outcomes vary from no sequelae to blindness or chronic headaches. No clear prognostic indicators exist. Treatment consists of medication, weight loss, and possibly surgical intervention.There is an unmet need of defining biomarkers with prognostic or diagnostic value and defining predictors of a poor outcome. This project is a prospective, population-based cohort study including clinical data and a biobank (blood samples and cerebrospinal fluid). The investigator's primary aim is to identify biomarkers of diagnostic or prognostic value and to create a clinical IIH database. The clinical database will answer questions about patient characteristics at baseline and during follow-up, identify predictors of outcome, and help create a standardized programme for follow-up and

NCT ID: NCT04004923 Completed - Clinical trials for Intracranial Pressure Increase

Intracranial Pressure in Monopolar and Bipolar Hysteroscopy

Start date: July 5, 2019
Phase: N/A
Study type: Interventional

Two distinction fluids are used in operative hysteroscopy. One is monopolar and the second is bipolar. The monopolar fluid contains mannitol and the bipolar fluid contains serum physiologic. This study aims to compare intracranial pressure in patients undergoing monopolar and bipolar hysteroscopy.

NCT ID: NCT03963336 Completed - Clinical trials for Idiopathic Intracranial Hypertension

Quantitative D-dimer Level and Anticoagulant Therapy in Idiopathic Intracranial Hypertension

Start date: July 22, 2017
Phase: Early Phase 1
Study type: Interventional

Idiopathic intracranial hypertension (IIH) is a syndrome characterized by elevated intracranial pressure (ICP) of unknown etiology. The investigators aim to study the quantitative D-dimer level and the role of anticoagulant therapy in the absence of occlusive sinus thrombosis in IIH patients.

NCT ID: NCT03957837 Completed - Clinical trials for Intracranial Hypertension

Optical Nerve Sheath Changes During Head Down Laparoscopy

Start date: May 13, 2019
Phase:
Study type: Observational

Patient undergoing laparoscopic radical prostatectomy in steep trendelenburg position are at risk to develop complication from brain edema. Ultrasound assessment of optical nerve sheath diameter is a simply, non-invasive method to estimate the increase of intracranial pressure. It is unknown how optical nerve sheath diameter changes after prolonged head down position.