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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05608122
Other study ID # KY-2021-110-01
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date October 30, 2022
Est. completion date October 1, 2023

Study information

Verified date November 2022
Source Beijing Tiantan Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

Intracranial aneurysm is the main cause of subarachnoid hemorrhage, and the incidence of subarachnoid hemorrhage in Chinese population is about 5%. The intervention of unruptured intracranial aneurysms is controversial because of its great harm after natural rupture and bleeding, and about a quarter of patients still have poor prognosis through existing invasive treatment methods. How to accurately determine the instability risk of unruptured intracranial aneurysms is the key to resolve this controversy. In previous studies, the stability of intracranial aneurysms involves many characteristics, and the sample size is small. Most of them are retrospective studies and studies on the status after change (rupture/growth). Therefore, the relevant risk factors are not clear at present, and there is still a lack of reliable prediction model. Based on the above facts, this study proposed based on the national hundred regional medical institutions set up the network registration platform of unruptured intracranial aneurysms, real time and openness of Internet, through the way of case resource sharing build unruptured intracranial aneurysm queue, collecting clinical characteristics, imaging features, hemodynamic detection of biological samples and the results of the analysis data, And observe them for two years. The artificial intelligence platform of Tonglian Medical Health was used to integrate and analyze and learn all the data, and then the risk factors related to the stability of intracranial aneurysms within two years were obtained, and the stability prediction model of unruptured intracranial aneurysms was constructed. This study will build the largest network registration platform and population follow-up cohort of unruptured intracranial aneurysms in China, and put forward a prediction model for the stability of unruptured intracranial aneurysms by integrating the multi-dimensional factors of intracranial aneurysms, so as to provide a powerful auxiliary judgment tool for the clinical decision-making of this disease.


Recruitment information / eligibility

Status Recruiting
Enrollment 1000
Est. completion date October 1, 2023
Est. primary completion date October 1, 2023
Accepts healthy volunteers No
Gender All
Age group 18 Years to 75 Years
Eligibility Inclusion Criteria: 1. 18-75 years old; 2. At least one unruptured intracranial aneurysm was found by CTA; 3. No relevant symptoms, receiving non-operative and conservative observation treatment; 4. Signing the informed consent. Exclusion Criteria: 1. Other cerebrovascular structural lesions (such as cerebrovascular malformation and arteriovenous fistula) or craniocerebral tumors; 2. Fusiform or dissecting aneurysms; 3. Traumatic, mycotic and atrial myxoma associated aneurysms; 4. Suffering from systemic connective tissue diseases, such as polycystic kidney disease; 5. Expectant survival of no more than 3 years due to other diseases or poor general conditions; 6. Patients refuse to follow up or cannot communicate with them due to mental diseases; 7. Pregnant women or participating in other aneurysm related studies.

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Obervation
This study is an observational study without any intervention
Obervation
This study is an observational study without any intervention

Locations

Country Name City State
China Beijing Tiantan Hospital Beijing Beijing

Sponsors (1)

Lead Sponsor Collaborator
Beijing Tiantan Hospital

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary Aneurysm rupture 2 years
Secondary Aneurysm growth 2 years
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