Intracranial Aneurysm Clinical Trial
Official title:
Epidemiology of Cerebral Aneurysms With MRA in China in Middle-aged or Elder Person: a Population-based Survey
The Chinese Cerebral Aneurysms Survey is a continuing prospective study among middle-aged and older individuals (35 - 75 years) that aims to determine the prevalence of cerebral intracranial aneurysms in the general population with MRA at 3.0 Tesla (T).
Cerebral intracranial aneurysms are common. In angiographic and autopsy studies, estimates
for prevalence vary between 0.2 and 9.9 percent. The methods used to detect the aneurysms
markedly influenced the proportion of aneurysms. Retrospective autopsy studies probably give
an underestimation and prospective angiography studies an overestimation of the actual
prevalence. Accurate data on the prevalence of intracranial aneurysms are essential in
evaluating the results of screening programs for aneurysms in general population.
During the past decade, MRA, as a preferred accuracy modality for noninvasive intracranial
vascular imaging at most centers, is playing an increasing role in the evaluation of
patients suspected of having intracranial aneurysms. In recurrent study, we have tested that
MRA at 3T has excellent sensitivity, accuracy, and correlation with DSA and is comparable to
catheter cerebral angiography for the evaluation of patients with intracranial aneurysms
(Stroke, in press). Therefore, we examined trends in intracranial aneurysm prevalence with
the use of MRA at 3.0T to determine the true prevalence of cerebral intracranial aneurysms
in the general middle-aged or elder population.
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Observational Model: Ecologic or Community, Time Perspective: Prospective
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