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Efficacy and Safety of Mirabegron in Intracerebral Hemorrhage

Intracerebral Haemorrhage Clinical Trial

Official title:
Efficacy and Safety of Mirabegron in Intracerebral Hemorrhage

Clinical Trial Summary

Intracerebral hemorrhage (ICH) accounts for 10-15% of all strokes without effective pharmacological treatment. Inflammation following ICH contributes to barrier disruption and peri-hematoma edema, leading to deterioration of neurological function. Preclinical evidence suggests that bone marrow hematopoietic stem and progenitor cells (HSPCs) are swiftly activated after ICH. Thereafter, these HSPCs produce an increased output of anti-inflammatory monocytes as an endogenous protective mechanism. Stimulation of β3 adrenergic receptor using selective agonists promotes the production of anti-inflammatory monocytes in bone marrow, and thereby reduces neuroinflammation, brain edema and neurological deficits. This study is to assess the safety and efficacy of a β3 adrenergic receptor agonist Mirabegron as a potential treatment option in ICH patients.

Clinical Trial Description

This study is to evaluate the efficacy and safety of mirabegron in patients with intracerebral hemorrhage based on standard therapy ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05369351
Study type Interventional
Source Tianjin Medical University General Hospital
Contact Handong Li
Phone +8615022439149
Email handongli90@foxmail.com
Status Recruiting
Phase Phase 2
Start date January 17, 2024
Completion date November 10, 2026
View Details
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