The Comparison of Uniportal and Tubeless Video Assisted Thoracic Surgery and Transbronchial Lung Cryobiopsy in the Diagnosis of Interstitial Lung Disease

Interstitial Lung Disease Clinical Trial

Official title:

The Comparison of Uniportal and Tubeless Video Assisted Thoracic Surgery and Transbronchial Lung Cryobiopsy Within the Multidisciplinary Discussion Context in the Diagnosis of Interstitial Lung Disease

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03958162
• Other study ID #: TS20181008
• Status: Not yet recruiting
• Phase: N/A
• Start date: June 1, 2019
• Est. completion date: June 1, 2020

Study information

• Verified date: May 2019
• Source: Guangzhou Institute of Respiratory Disease
• Contact: Xiaobo Chen, Doctor
• Phone: +8613751721744
• Email: xiaobo-win[@]163.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To compariing the uniportal and tubeless video assisted thoracic surgery and trnsbronchial lung cryobiopsy within the multidisciplinary discussion context in the diagnosis of interstitial lung disease，and assess the safety and cost-effectiveness. This is a prospective control trial.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 60
• Est. completion date: June 1, 2020
• Est. primary completion date: June 1, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

1. 18 yrs = age<75yrs

2. Patients diagnosed as interstitial lung disease with comprehensive clinical data (including history, serological test, spirometry test and high resolution computed tomography)

3. Further pathological data was still required after multidisciplinary discussion.

Exclusion Criteria:

1. Severe pulmonary dysfunction: forced vital capacity (FVC) =65% or carbon-monoxide diffusion coefficient (DLco) =45% of predicted value

2. Pulmonary hypertension: An estimated systolic pulmonary artery pressure>50mmHg on echocardiography

3. Abnormal coagulation parameters or thrombocytopenia (<50*109/L)

4. Severe comorbidities leading to inoperable condition

5. Patients cannot give consent or refuse biopsy

Related Conditions & MeSH terms

• Interstitial Lung Disease
• Lung Diseases
• Lung Diseases, Interstitial
• Surgical Lung Biopsy
• Transbronchial Lung Cryobiopsy

Intervention

Diagnostic Test:
• lung biopsy
transbronchial lung cryobiopsy

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Guangzhou Institute of Respiratory Disease

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Diagnotic yield	Percentage of definitive diagnosis within the multidisciplinary discussion context by two different biopsy methods	two weeks