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Intermittent Hypoxia clinical trials

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NCT ID: NCT00646971 Terminated - Oxidative Stress Clinical Trials

Oxidative Stress and Endothelial Dysfunction in Obstructive Sleep Apnea

SOREVAS
Start date: January 2008
Phase: N/A
Study type: Interventional

Patients with sleep apnea syndrome have repeated apneic events that induce periodic hypoxia-reoxygenation, drawing away an overproduction of oxidants. This exaggerated generation of oxidants is associated with a dysfunction of the vascular endothelium that evolves, in its turn, towards cardiovascular diseases such as systemic hypertension, stroke, and myocardial infarction. The major aim of our study is to examine the effect of CPAP treatment on biochemical (markers of oxidative stress) and functional (endothelium-dependent vascular relaxation reactivity) abnormalities at 1 and 4 weeks of treatment.