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NCT04083482 Clinical Trial

Removal of mtDNA in Plasma by Continous Venovenous Hemofiltration in Sepsis

Intensive Care Unit Clinical Trial

Official title:
Removal of mtDNA in Plasma by Continous Venovenous Hemofiltration in Sepsis

Clinical Trial Details — Status: Enrolling by invitation

Administrative data
NCT number NCT04083482
Other study ID # WYJ2019
Secondary ID
Status Enrolling by invitation
Phase N/A
First received
Last updated
Start date August 20, 2018
Est. completion date December 31, 2019

Study information
Verified date September 2019
Source First People's Hospital of Chenzhou
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The plasma level of mtDNA in sepsis is affected by continous venovenous hemofiltation（CVVH）

Description:

Continous renal replacement therapy （CRRT）has become routine for patients with chronic renal failure ，AKI，fliud overload as well as oliguria in ICU .In clinical patients ，continous venovenous hemofoiltration （CVVH）is actually the method of chioce for CRRT in critically ill and hemodynamic instable patients .CVVH has significant beneficial effects on removing inflammatory cytokines ，improving oxygen index，increasing cardiac index and regulating immune dysfuntion .

Recruitment information / eligibility
Status Enrolling by invitation
Enrollment 20
Est. completion date December 31, 2019
Est. primary completion date September 20, 2018
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

Adult septic patients undergoing CRRT

Exclusion Criteria:

1. Missing vists

2. transplatation

3. cancer

4. aquired immunodeficiency syndrome

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• continous venovenous hemofiltraion
CVVH

Locations
Country Name City State
China The First Hospital of Chenzhou Chenzhou Hunan

Sponsors (1)
Lead Sponsor Collaborator
First People's Hospital of Chenzhou

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary Change of mtDNA concentration in plasma The specimens in the prefilter and postfilter blood as well as in the ultrafiltrate were obtained at the beginning of CRRT (T0) and 6 h (T6h), 12 h (T12h) after the setup of CVVH. befor,6hours, 12hours, after CVVH treatment
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