Comparing the Effects of Different Types of Exercise on Glucose Handling

Status Completed

Clinical Trial Summary

The purpose of the proposed study is to compare the acute effects of different types of exercise modalities on glucose handling in young, healthy males and females. The exercise modalities that will be compared include: a high intensity interval exercise (HIIE) protocol, a moderate intensity continuous exercise (MICE) protocol and a low-load, high-repetition (LL-HR) resistance exercise protocol.

Clinical Trial Description

The purpose of this study is to compare the effects of different exercise modalities (High intensity interval exercise, Moderate intensity continuous exercise, and Low-load-high repetition resistance exercise) on blood sugar control in young healthy, males and females. To test this theory, a sugar challenge (oral glucose tolerance test - OGTT) will be performed during the pre-testing visit to determine the baseline blood sugar response. An OGTT will also be performed 2 hours after each single exercise session to determine how each type of exercise affects the blood sugar response. Investigators will take multiple blood samples throughout the trial to allow us to measure blood sugar, insulin and concentrations and oxidative stress. Muscle biopsies will be taken before and after each exercise bout so that investigators can examine the underlying mechanisms that contribute to the effectiveness of the different types of exercise on blood sugar control. Investigators will also use an ultrasound to measure factors related to of cardiovascular health such as artery stress and vascular conductance during the exercise bouts. Direct benefits of this study include characterizing sex differences of blood sugar handling after single exercise sessions. This study could have direct benefits on deterring the effectiveness of different forms of exercise on blood sugar levels. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06217679
Study type	Interventional
Source	University of Waterloo
Contact
Status	Completed
Phase	N/A
Start date	May 1, 2018
Completion date	October 31, 2019

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03458741` - How is Glycogen Supercompensation Regulated in Human Skeletal Muscle	N/A
Recruiting	`NCT06042517` - Mechanisms of Ultrasound Neuromodulation Effects in Diabetes	N/A
Completed	`NCT03859934` - Metabolic Effects of Melatonin Treatment	Phase 1
Completed	`NCT03689738` - Effects of Potato Resistant Starch Intake on Insulin Sensitivity, Related Metabolic Markers and Satiety	N/A
Recruiting	`NCT04195165` - The Effect of Sitting and Moderate Exercise on Plasma Insulin and Glucose Responses to an Oral Glucose Tolerance Test	N/A
Recruiting	`NCT05441982` - Saccharin and Acesulfame Potassium Consumption and Glucose Homeostasis in Older Adults With Prediabetes	N/A
Terminated	`NCT03325933` - Resistance Training and Cardiometabolic Health	N/A
Recruiting	`NCT05791968` - Blood Donation Could Improve Insulin Sensitivity	N/A
Completed	`NCT02913079` - The Acute Impact of Sit-stand Desks on Post-meal Blood Sugar Levels	N/A
Suspended	`NCT03240978` - Exercise Intervention for the Prevention of Prediabetes in Overweight Chinese	N/A
Completed	`NCT02700698` - Mitochondrial Function in Circulating Cells and Muscle Tissue
Recruiting	`NCT01972113` - Vitamin K and Glucose Metabolism in Children at Risk for Diabetes (Vita-K 'n' Kids Study)	N/A
Completed	`NCT02058914` - Effects of Sugar Sweetened Beverage on Metabolic Health in Male and Female Adolescents	N/A
Enrolling by invitation	`NCT02192684` - Obesity, Sleep Apnea, and Insulin Resistance	N/A
Completed	`NCT00936130` - Bariatric Surgery and Weight Loss on Energy Metabolism and Insulin Sensitivity	N/A
Completed	`NCT01216956` - Metabolic Effects of an 8 Week Niaspan Treatment in Patients With Abdominal Obesity and Mixed Dyslipidemia	N/A
Recruiting	`NCT05992688` - The Sweet Kids Study (Stevia on Weight and Energy Effect Over Time)	N/A
Recruiting	`NCT04168372` - Fructose: Substrate, Stimulus, or Both?	N/A
Recruiting	`NCT05443347` - Activity, Adiposity, and Appetite in Adolescents 2 Intervention	N/A
Terminated	`NCT04239482` - Nutritional Supplementation and Insulin Sensitivity	N/A