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Blood Donation Could Improve Insulin Sensitivity — GLUCFER  

Insulin Sensitivity Clinical Trial

Official title:
Effects of a Standard Blood Bank Donation on Insulin Sensitivity in Adults With Pre-diabetes and Abdominal Obesity

Clinical Trial Summary

Studies in the literature suggest that people with obesity have an excess of stored iron. There is possibly an inverse relationship between ferritin levels and the actions of insulin on glycemic control. The reduction of stored iron by simply donating blood could result in improvements in glycemic control in people with obesity and prediabetes. We propose, to reduce ferritin levels through a standard donation of a unit of whole blood, and to measure if it positively affects glycemic control.

Clinical Trial Description

Individuals with pre-diabetes and abdominal obesity will be randomized to either a donation group (DON) or a control group (CONT) in a double-blind fashion (RCT). Insulin sensitivity during an oral glucose tolerance test (OGTT) and isotopically measured rate of appearance of endogenous and exogenous glucose will be measured on 2 occasions. 1. Two weeks prior to DON/CONT 2. Two weeks after to DON/CONT Indexes of the bodily iron stores will be measured after DON/CONT to evaluate if the primary treatment was effective. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05791968
Study type Interventional
Source University of Castilla-La Mancha
Contact Ricardo Mora-Rodriguez, PhD
Phone 925268800
Email ricardo.mora@uclm.es
Status Recruiting
Phase N/A
Start date September 2023
Completion date March 2024
View Details
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