Effect of Camel Milk on Insulin and Incretin Response

Insulin Sensitivity Clinical Trial

Official title:

The Effect of Camel Milk on Insulin and Incretin Response to a Mixed-meal Challenge in People With Normal Glucose Tolerance

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03725969
• Other study ID #: IREC033
• Status: Recruiting
• Phase: N/A
• Start date: February 1, 2017
• Est. completion date: December 30, 2020

Study information

• Verified date: February 2020
• Source: Imperial College London Diabetes Centre
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To examine the differential effect of camel and cow milk on the physiological response, to a liquid mixed-meal challenge, in people with normal glucose tolerance

Description:

Camel milk is used as a traditional remedy throughout the Middle East and Indian Subcontinent for conditions such as type 2 diabetes and dyslipidemia. It is currently unclear how such an effect could be mediated in vivo and studies are limited. We performed this study as a pilot experiment to assess the effects of camel milk on Insulin, Glucose, GLP-1, C-peptide and Lipid profile.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 15
• Est. completion date: December 30, 2020
• Est. primary completion date: December 30, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 70 Years

Eligibility

Inclusion Criteria:

• Normal glucose tolerance

• BMI < 30 kg/m2

Exclusion Criteria:

• Type 1 diabetes mellitus

• Type 2 diabetes mellitus

• Impaired fasting glucose or impaired glucose tolerance

• Lactose intolerance

• Weight loss / gain = 5 kg in the preceding two months

• Use of estrogenic drugs or corticosteroids

• Known hypertriglyceridemia requiring treatment

• History of heart attack, angina or cardiovascular disorder

• History of malignant tumor

• Pregnant or lactating women

• Hemoglobin < 12 for any reason

• Recent surgery or major hemorrhage

• History of bariatric or metabolic surgery

Related Conditions & MeSH terms

• Glucose Tolerance
• Insulin Resistance
• Insulin Sensitivity

Intervention

Dietary Supplement:
• Camel milk
Camel Milk administered 10 minutes before a mixed meal of carbohydrate and protein; 2-week washout between interventions
• Cow milk
Cow milk administered 10 minutes before a mixed meal of carbohydrate and protein;2-week washout between interventions

Locations

Country	Name	City	State
United Arab Emirates	Imperial College London Diabetes Centre	Abu Dhabi

Sponsors (1)

Lead Sponsor	Collaborator
Imperial College London Diabetes Centre

Country where clinical trial is conducted

United Arab Emirates, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Glucose response to camel and cow milk	The difference between interventions in terms of peak of glucose	5 months
Primary	Response of glucose to camel and cow milk	The difference between interventions in terms of area under the curve	5 months
Secondary	Insulin response to camel and cow milk	The difference between interventions in terms of peak	5 months
Secondary	Response of insulin to camel and cow milk	The difference between interventions in terms of area under the curve	5 months
Secondary	GLP-1 response to camel and cow milk	The difference between interventions in terms of peak	5 months
Secondary	Response of GLP-1 to camel and cow milk	The difference between interventions in terms of area under the curve	5 months
Secondary	C-peptide response to camel and cow milk	The difference between interventions in terms of peak	5 months
Secondary	Response of C-peptide to camel and cow milk	The difference between interventions in terms of area under the curve	5 months