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Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults — EJB050  

Insulin Sensitivity Clinical Trial

Official title:
Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults

Clinical Trial Summary

The investigators are studying the effects of Hyperglycemia on vascular function and insulin sensitivity on healthy adults

Clinical Trial Description

The investigators will study 22 healthy subjects (18-35 yrs) four times as follows: 1. Saline + Octreotide + euglycemia; 2. Octreotide + hyperglycemia; 3. Octreotide + hyperglycemia + insulin clamp and 4. Octreotide + Euglycemia + insulin clamp. The sequence of admissions will be assigned randomly. The investigators will assess function in conduit (pulse wave velocity-PWV, augmentation index-AI and flow-mediated dilation-FMD), resistance (post-ischemic flow velocity-PIFV) and heart and skeletal muscle microvascular (contrast enhanced ultrasound-CEU) vessels. This work will: a) identify whether vascular stiffness and indices of NO action are impaired throughout the arterial tree with hyperglycemia. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03520569
Study type Interventional
Source University of Virginia
Contact
Status Completed
Phase Early Phase 1
Start date February 4, 2019
Completion date April 1, 2021
View Details
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