Insulin Sensitivity Clinical Trial
Official title:
Assessment of Renin Inhibition on Insulin Sensitivity, Diastolic Function and Aortic Compliance
This study is an investigation of the effect of commonly prescribed anti-hypertensive agents
on insulin sensitivity, diastolic function and aortic compliance. The aims of the study are
as follows:
Specific Aim 1: To determine in insulin resistant, hypertensive subjects if renin inhibition
for 12 weeks modifies glucose homeostasis and insulin sensitivity.
To accomplish this specific aim, we will use three approaches: a fasting HOMA Index; and a
three hour glucose tolerance test. Only hypertensive subjects with insulin resistance, as
assessed by HOMA index will be enrolled in the study. Insulin resistance will be assessed
basally and after twelve weeks of treatment with either a calcium channel blocker with
placebo, or calcium channel blocker with a renin inhibitor, or a calcium channel blocker with
a renin inhibitor and an angiotensin receptor antagonist.
Specific Aim 2: To determine in insulin resistant, hypertensive subjects if renin inhibition
for 12 weeks modifies diastolic function and aortic compliance response to dietary sodium
intake.
The same protocol and subjects will be used as defined in Specific Aim 1. Myocardial
relaxation velocity (tissue Doppler imaging at the mitral annulus) and aortic compliance
(characteristic aortic impedance) will be measured at baseline and then after acute and
chronic renin inhibition:
1. Acute effect of renin inhibition: Hemodynamic measurements will be obtained on both high
and low dietary sodium intake conditions (~1 week each) before and after a single dose
of a renin inhibitor.
2. Chronic effect of renin inhibition: Hemodynamic measurements will be obtained at
baseline and after 12 weeks of each of the three drug treatment arms above.
The study lasts 12 weeks and plans to study 45 hypertensive adults over the next two years.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03458741 -
How is Glycogen Supercompensation Regulated in Human Skeletal Muscle
|
N/A | |
| Recruiting |
NCT06042517 -
Mechanisms of Ultrasound Neuromodulation Effects in Diabetes
|
N/A | |
| Completed |
NCT03859934 -
Metabolic Effects of Melatonin Treatment
|
Phase 1 | |
| Completed |
NCT03689738 -
Effects of Potato Resistant Starch Intake on Insulin Sensitivity, Related Metabolic Markers and Satiety
|
N/A | |
| Recruiting |
NCT04195165 -
The Effect of Sitting and Moderate Exercise on Plasma Insulin and Glucose Responses to an Oral Glucose Tolerance Test
|
N/A | |
| Recruiting |
NCT05441982 -
Saccharin and Acesulfame Potassium Consumption and Glucose Homeostasis in Older Adults With Prediabetes
|
N/A | |
| Terminated |
NCT03325933 -
Resistance Training and Cardiometabolic Health
|
N/A | |
| Recruiting |
NCT05791968 -
Blood Donation Could Improve Insulin Sensitivity
|
N/A | |
| Completed |
NCT02913079 -
The Acute Impact of Sit-stand Desks on Post-meal Blood Sugar Levels
|
N/A | |
| Suspended |
NCT03240978 -
Exercise Intervention for the Prevention of Prediabetes in Overweight Chinese
|
N/A | |
| Completed |
NCT02700698 -
Mitochondrial Function in Circulating Cells and Muscle Tissue
|
||
| Recruiting |
NCT01972113 -
Vitamin K and Glucose Metabolism in Children at Risk for Diabetes (Vita-K 'n' Kids Study)
|
N/A | |
| Completed |
NCT02058914 -
Effects of Sugar Sweetened Beverage on Metabolic Health in Male and Female Adolescents
|
N/A | |
| Enrolling by invitation |
NCT02192684 -
Obesity, Sleep Apnea, and Insulin Resistance
|
N/A | |
| Completed |
NCT00936130 -
Bariatric Surgery and Weight Loss on Energy Metabolism and Insulin Sensitivity
|
N/A | |
| Completed |
NCT01216956 -
Metabolic Effects of an 8 Week Niaspan Treatment in Patients With Abdominal Obesity and Mixed Dyslipidemia
|
N/A | |
| Recruiting |
NCT05992688 -
The Sweet Kids Study (Stevia on Weight and Energy Effect Over Time)
|
N/A | |
| Recruiting |
NCT04168372 -
Fructose: Substrate, Stimulus, or Both?
|
N/A | |
| Recruiting |
NCT05443347 -
Activity, Adiposity, and Appetite in Adolescents 2 Intervention
|
N/A | |
| Terminated |
NCT04239482 -
Nutritional Supplementation and Insulin Sensitivity
|
N/A |