Insulin Resistance in Relation to Hyperthyroidism and Hypothyroidism

Insulin Resistance Clinical Trial

Official title:

Insulin Resistance in Relation to Hyperthyroidism and Hypothyroidism

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06399796
• Other study ID #: Thyroid and insulin resistance
• Status: Not yet recruiting
• Start date: June 1, 2024
• Est. completion date: July 1, 2025

Study information

• Verified date: May 2024
• Source: Assiut University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Insulin resistance and its relation to hyperthyrodism and Hypothyroidism

Description:

Thyroid hormones (TH) play an important role in regulating energy balance, metabolism of glucose, and lipids. While TH oppose the action of insulin and stimulate the hepatic gluconeogenesis and glycogenolysis they up-regulate the expression of genes such as glucose transporter type-4 (GLUT--4) and phosphoglycerate kinase, involved in glucose transport and glycolysis, respectively, thus acting synergistically with insulin facilitating glucose disposal and utilization in peripheral tissues.

This indicates a possible interplay between thyroid status and insulin sensitivity. Homeostatic model assessment (HOMA) is a method for assessing β-cell function and insulin resistance (IR) from basal (fasting) glucose and insulin or C-peptide concentrations. The homeostasis model assessment (HOMA) for IR (HOMA-IR) derives estimates of insulin sensitivity from the mathematical modeling of fasting plasma glucose and insulin concentrations.

Homeostatic model assessment for insulin resistance (HOMA - IR) based on fasting glucose and insulin measurements; derived from the product of the insulin and glucose values divided by a constant, that is, calculated by using the following formula: fasting glucose (mg/dL) X fasting insulin (mU/L) / 405 (for SI units: fasting glucose (mmol/L) X fasting insulin (mU/L) / 22.5) , a value greater than 2 indicates insulin resistance .

In both hyper- as well as hypothyroid groups, there was significant increase in LDL levels. The amount of insulin specifically bound and the number of insulin receptors per cell were inversely correlated with the LDL level. The number of insulin receptors and the amount of insulin bound in the tested subjects with increased LDL were correspondingly low.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 100
• Est. completion date: July 1, 2025
• Est. primary completion date: June 1, 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Adult pations above 18 years old

Exclusion Criteria:

• Any patients with Diabetes mellitus

Related Conditions & MeSH terms

• Hyperthyroidism
• Hypothyroidism
• Insulin Resistance

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

References & Publications (6)

Chubb SA, Davis WA, Davis TM. Interactions among thyroid function, insulin sensitivity, and serum lipid concentrations: the Fremantle diabetes study. J Clin Endocrinol Metab. 2005 Sep;90(9):5317-20. doi: 10.1210/jc.2005-0298. Epub 2005 Jun 28. — View Citation

Clement K, Viguerie N, Diehn M, Alizadeh A, Barbe P, Thalamas C, Storey JD, Brown PO, Barsh GS, Langin D. In vivo regulation of human skeletal muscle gene expression by thyroid hormone. Genome Res. 2002 Feb;12(2):281-91. doi: 10.1101/gr.207702. — View Citation

Mari A, Ahren B, Pacini G. Assessment of insulin secretion in relation to insulin resistance. Curr Opin Clin Nutr Metab Care. 2005 Sep;8(5):529-33. doi: 10.1097/01.mco.0000171130.23441.59. — View Citation

Raboudi N, Arem R, Jones RH, Chap Z, Pena J, Chou J, Field JB. Fasting and postabsorptive hepatic glucose and insulin metabolism in hyperthyroidism. Am J Physiol. 1989 Jan;256(1 Pt 1):E159-66. doi: 10.1152/ajpendo.1989.256.1.E159. — View Citation

Sanghvi A, Virji MA, Warty V, Dimasi MJ. Differential suppression of lymphocyte cholesterol synthesis by low density lipoprotein and erythrocyte insulin receptors in normolipidemic subjects. Atherosclerosis. 1983 Dec;49(3):307-18. doi: 10.1016/0021-9150(83)90141-7. — View Citation

Singh BM, Goswami B, Mallika V. Association between insulin resistance and hypothyroidism in females attending a tertiary care hospital. Indian J Clin Biochem. 2010 Apr;25(2):141-5. doi: 10.1007/s12291-010-0026-x. Epub 2010 May 27. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The prevalence of diabetes mellitus among patients with thyroid disorders	to prove the prevalence of diabetes mellitus is elevated among patients with thyroid disorders	baseline