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Clinical Trial Summary

The goal of this study is to evaluate the efficacy of metformin on insulin sensitivity and vascular endothelial function with respect to gut microbiota and metabolome in women with established insulin resistance and its tolerance after 12 weeks of probiotic therapy. The hypothesis is probiotic therapy in women with established insulin resistance undergoing metformin treatment increases the drug's efficacy to improve insulin sensitivity and intestinal endothelial function, and reduces gastrointestinal side effects. Study participants will be randomly assigned to 2 groups, taking a probiotic (GS) or a placebo (GP). The randomization scheme will be computer-generated using permuted blocks of block size 4.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06092060
Study type Interventional
Source Poznan University of Physical Education
Contact
Status Completed
Phase N/A
Start date April 1, 2021
Completion date July 20, 2023

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