Metabolic Heterogeneity Underlying Hypertriglyceridemia: Hepatic

Status Recruiting

Clinical Trial Summary

The focus of this cross-sectional study is to determine the effects of tissue-specific (adipose tissue or muscle) vs global (combined) insulin resistance (IR) on hepatic triglyceride biosynthesis in humans, and to determine differential effects of an acute exercise intervention on hepatic triglyceride biosynthesis in these groups.

Clinical Trial Description

Hypothesis: Patients who primarily have muscle IR will have a greater percentage of lipids derived from de novo lipogenesis (DNL) than patients with combined muscle and adipose IR, and these subjects will respond more robustly to the effects of premeal exercise. With this study, the investigators will demonstrate that the mechanisms that drive triglyceride overproduction in insulin-resistant humans are dependent on which tissues are insulin resistant. To this end, investigators will determine whether subjects with muscle insulin resistance and adipose tissue insulin resistance utilize different mechanisms of triglyceride biosynthesis to assemble hepatic very low density lipoprotein (VLDL), as compared with individuals with muscle insulin resistance but relative adipose tissue insulin sensitivity. Additionally, investigators will see if adipose tissue insulin sensitivity predicts exercise responsiveness of hepatic triglyceride production. Main study parameters/endpoints: Difference in %DNL between subjects with global vs muscle-only insulin resistance as well as the differential effects of premeal exercise on %DNL in these groups. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05743868
Study type	Interventional
Source	Yale University
Contact	Daniel F Vatner, MD, PhD
Phone	203 785 5934
Email	daniel.vatner@yale.edu
Status	Recruiting
Phase	N/A
Start date	November 16, 2023
Completion date	August 2024

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Metabolic Heterogeneity Underlying Hypertriglyceridemia: Hepatic Triglyceride Biosynthesis in Humans With Different Insulin Resistance Phenotypes

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms