Insulin Resistance Clinical Trial
Official title:
Impact of a Supplement of Vegetable Oils on Body Weight and Composition, Insulin Sensitivity and Other Cardiovascular Risk Factors in People at Risk of Developing Type 2 Diabetes Mellitus.
Metabolic and cardiovascular diseases are the first cause of morbidity and mortality throughout the world, including Latin America and Colombia. Asymptomatic elevations of blood glucose, insufficient response to normal insulin concentrations (called insulin resistance), overweight and obesity can cause severe damage to body organs, leading to complications and even death. Worryingly, the prevalence of prediabetes is on the rise and efforts in public health policies made to contain this epidemic have had a very limited impact. This has prompted an intense search for non-pharmacological interventions. One of the most promising areas is research on "nutraceuticals", foods capable of positively impacting risk factors. However, there are insufficient nutritional or supplementary alternatives to favorably impact carbohydrate metabolism and cardiovascular risk factors in individuals at risk of diabetes. This project will evaluate the effects of the administration of a dietary supplement composed of vegetable oils. The fat composition of these oils is likely to impact positively on the metabolic profile of subjects at risk of diabetes and cardiovascular conditions.
Chronic non-communicable diseases (NCDs) account for 63% of deaths worldwide, of which 80%
occur in low- and middle-income countries In Colombia, 71% of all deaths are related to NCDs
. This pandemic can be prevented by controlling the risk factors, seeking to create
interventions that impact more than one risk factor at a time, including body weight, blood
glucose levels, blood pressure, cardiorespiratory fitness and other relatively minor risk
factors.
On the other hand, diabetes mellitus is a major cause of morbidity and mortality worldwide .
In its natural history, diabetes is preceded by factors that confer risk of diabetes and for
a group of disorders known as "prediabetes" term comprising intolerance carbohydrates and
impaired fasting glycaemia . Although people at risk of diabetes or prediabetes are often
asymptomatic; lesions develop in micro and macrovascular beds and result in long-term kidney
dysfunction, retinal damage and affectation of peripheral nerves and arteries. Vascular
damage leads to an increased risk of retinopathy renal insufficiency , painful or autonomic
neuropathy and atherosclerotic cardiovascular threatening diseases such as acute myocardial
infarction.
The above situation has prompted an intense search for non-pharmacological interventions to
intervene in patients at risk of diabetes and prevent negative consequences on the body in
the short, medium and long term. One of the most promising areas of research is the
nutraceuticals field. Colombian Team Foods S.A has developed a supplement of vegetable oils,
that for their composition could have the ability to improve pathophysiological phenomena
associated with the development of diabetes and its complications.
The main objective of this trial is to assess the impact of the consumption of a vegetable
oils-based designed jointly by Team Foods and university of los Andes, on several indicators
metabolic health in people at risk of diabetes. The specific objectives are:
- To enroll a sample of patients who are at risk of diabetes but have not receive drugs to
control plasma glucose, cholesterol or triglycerides, and have not developed
complications like kidney or eye dysfunction.
- To evaluate the effect of daily consumption of the study supplement on fasting blood
glucose, the area under the glucose curve in an oral glucose tolerance test, and
glycated hemoglobin (HbA1c-an indicator of blood glucose levels over the last 3 months).
- To evaluate the effect of the supplement on indexes and biomarkers of insulin
resistance.
- To evaluate the effect of the supplement on other cardiovascular risk factors including
lipid profile, blood pressure, body weight and body composition.
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