Effect of Weight Loss on Brain Insulin Sensitivity in Humans

Status Recruiting

Clinical Trial Summary

Obesity if known to be associated with brain insulin resistance in humans. This condition has not only implication for the brain but also for whole-body energy homeostasis. Research in rodents indicates that weight loss is able to improve insulin sensitivity of the brain. The current project will test this hypothesis in humans. Therefore, brain insulin sensitivity will be assessed by fMRI in combination with intranasal insulin administration, using an established protocol. Furthermore, effects of daily administration of insulin nasal spray (versus placebo) over 8 weeks will be assessed as secondary (exploratory) variables.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Insulin Resistance

Clinical Trial Details

NCT number	NCT02991365
Study type	Interventional
Source	University Hospital Tuebingen
Contact	Andreas Fritsche, MD
Phone	+49 7071 29 80687
Email	andreas.fritsche@med.uni-tuebingen.de
Status	Recruiting
Phase	N/A
Start date	December 2016
Completion date	December 2024

View Details

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