Can Brief High-intensity Interval Training Mitigate the Adverse Consequences of High-fat Overfeeding?

Insulin Resistance Clinical Trial

— GAINHIT  

Official title:

Can Brief High-intensity Interval Training Mitigate the Adverse Consequences of High-fat Overfeeding?

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT02177604
• Other study ID #: 140319
• Status: Terminated
• Phase: N/A
• Start date: November 2014
• Est. completion date: December 2016

Study information

• Verified date: May 2018
• Source: University of Adelaide
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Previous research has shown that indulging in 50% more calories than required for as little as 3 days can significantly impact markers of metabolic health in lean and overweight individuals. Here, the investigators will determine if 3 brief sessions of high-intensity interval training can mitigate the adverse consequences of 7 days high-fat overfeeding in sedentary, overweight males.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 7
• Est. completion date: December 2016
• Est. primary completion date: December 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Sedentary (no more than 2 sessions of structured moderate intensity aerobic exercise or resistance training per week)

• Overweight (BMI 25-29.9 kg/m2)

Exclusion Criteria:

• Personal history of any major illness (i.e. cardiovascular disease, diabetes, hypertension, cancer, renal/liver impairments, major psychiatric disorders, eating disorders etc.)

• History of chest pain (either at rest or during exercise.)

• Abnormal resting ECG at screening visit

• Chronic use of any prescribed or non-prescribed medications (i.e. anti-hypertensive, statins, metformin, anti-inflammatories, antidepressants etc.)

• Blood pressure or blood lipids outside of reference ranges

• Serum ferritin <30ng/mL

• Uncontrolled asthma, current fever, or upper respiratory infection

• Current intake of > 140g alcohol/week

• Current smokers of cigarettes/cigars/marijuana

• Current intake of any illicit substance

• Experience claustrophobia in confined spaces

• Donated blood in the past 3 months

• Migraines

• Unable to comprehend study protocol

• Unable to perform exercise on a cycle ergometer at second screening visit

Related Conditions & MeSH terms

• Insulin Resistance

Intervention

Other:
• Wingate HIT
3 sessions of Wingate based High-Intensity Interval Training (6-8 x 15 second "all out" sprints on a cycle ergometer interspersed by 2 minutes recovery)
• Modified HIT
3 sessions of Modified High-Intensity Interval Training (8 x 60 second sprints at approximately 90-95% VO2 peak on a cycle ergometer interspersed by 60 seconds recovery)
• High-fat overfeeding
7 days of high-fat overfeeding (50% excess calories)

Locations

Country	Name	City	State
Australia	South Australian Health & Medical Research Institute	Adelaide	South Australia

Sponsors (3)

Lead Sponsor	Collaborator
University of Adelaide	Royal Adelaide Hospital, University of South Australia

Country where clinical trial is conducted

Australia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Change in mitochondrial metabolism	Changes in citrate synthase activity, mitochondrial DNA content and protein levels of PGC-1a	1 week
Other	Change in resting energy expenditure	Changes in resting energy expenditure measured by metabolic cart	1 week
Other	Change in cognitive function	Changes in cognitive function, assessed by a series of computer tasks involving vigilant attention and speed processing.	1 week
Primary	Change in glucose metabolism	Changes in insulin and glucose area under the curve assessed via 75g Oral Glucose Tolerance Test.	1 week
Secondary	Change in plasma levels of cytokines	Change in plasma levels of adiponectin, irisin, sex hormone-binding globulin and c-reactive protein	1 week