Insulin Resistance Clinical Trial
Official title:
Osteoprotegerin, Fibroblast Growth Factor 23 and Vitamin D3 Levels in Male Patients With Hypogonadism
The aim of this study is to investigate the markers of bone mineral metabolism in an unconfounded group of patients with hypogonadism and to search for a relationship between endothelial dysfunction and insulin resistance.
Cardiometabolic disorders are prevalent in patients with hypogonadism. Endothelial
dysfunction and insulin resistance are used in determining cardiovascular risk. The role of
markers of bone mineral metabolism in hypogonadism is not clearly presented.
49 male patients with hypogonadotropic hypogonadism (HH) and 43 BMI and age matched healthy
male subjects were enrolled. Osteoprotegerin (OPG), fibroblast growth factor-23 (FGF-23),
vitamin D and asymmetric dimethylarginine (ADMA) levels were measured. The insulin
sensitivity was estimated by homeostatic model assessment-insulin resistance (HOMA-IR)
formula.
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Observational Model: Case Control, Time Perspective: Cross-Sectional
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