Cardiovascular Effects of Metformin on Obesity

Status Withdrawn

Clinical Trial Summary

It has been shown that asymptomatic obese adolescents can demonstrate abnormal regional myocardial contraction, with preserved global cardiac function. Metformin has been shown to decrease cardiovascular mortality in patients with type 2 diabetes and insulin resistance, but the mechanism of cardiovascular protection is unknown.

The purpose of this study is to evaluate the reversibility of subclinical cardiovascular abnormalities in obese adolescents with insulin resistance after a six-month course of Metformin. The investigators hypothesized that the beneficial effects of Metformin will be progressive and sustained after six months of therapy.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Insulin Resistance

Clinical Trial Details

NCT number	NCT01910246
Study type	Interventional
Source	University of California, San Francisco
Contact
Status	Withdrawn
Phase	Phase 4
Start date	April 2015
Completion date	October 2016

View Details

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