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Predictors of Response to Fenofibrate — PreFar  

Insulin Resistance Clinical Trial

Official title:
Pretreatment Genotyping at APOA5 and GCKR Loci and Response to Fenofibrate Therapy

Clinical Trial Summary

Fenofibrate is one of the best options for treating hypertriglyceridemia. In the majority of patients, fenofibrate lowers triglycerides (TG) by 24-55% and improves HDL- and LDL-cholesterol. However, the response to fenofibrate is highly variable and currently there are no screening tests to identify poor responders. Genetic and environmental factors may explain the high variability in response. Although exploratory in nature, this study is of clinical and public health importance because prediction of drug response among those with hypertriglyceridemia is clinically challenging and fenofibrate prescription costs are large ($90 to $130/patient/month); targeting the responsive patients at the outset will help improve treatment outcomes at a lower cost. If successful, the investigators will propose to conduct a large, randomized trial on the effect of pre-prescription genotyping on fenofibrate response.

Clinical Trial Description

n/a

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01023750
Study type Observational
Source University of Alabama at Birmingham
Contact
Status Completed
Phase Phase 4
Start date January 2010
Completion date July 2012
View Details
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