Cardiovascular and Metabolic Responses to a Mixed Meal

Insulin Resistance Clinical Trial

Official title:

Role of Exercise Training and Body Weight on Cardiovascular and Metabolic Responses to a Mixed Meal Tolerance Test

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00882986
• Other study ID #: 1121717
• Status: Completed
• Phase: N/A
• First received: April 14, 2009
• Last updated: September 22, 2015
• Start date: January 2009
• Est. completion date: August 2011

Study information

• Verified date: September 2015
• Source: University of Kansas Medical Center
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

The purpose is to determine whether regular endurance exercise and/or body weight influence the way our nervous and vascular systems respond during the metabolism of meals.

Description:

To begin to examine this question we recruited healthy endurance-trained (high fit, HF) and normally active (average fit, AF) subjects. It is well characterized that chronic endurance training results in enhanced peripheral insulin sensitivity. Therefore, our rationale was that inclusion of two healthy subject groups, with distinct differences in insulin sensitivity, would allow us to investigate how enhanced insulin sensitivity influences insulin-mediated changes in central sympathetic outflow. Direct measurements of central sympathetic outflow to skeletal muscle (i.e., MSNA) were recorded, and a mixed meal was used as a physiological method to evoke robust and sustained increases in MSNA, which have been primarily attributed to insulin. We hypothesized that HF subjects would have a greater MSNA response, for a given plasma insulin concentration, following consumption of a mixed meal (i.e., greater central insulin sensitivity).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: August 2011
• Est. primary completion date: August 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 20 Years to 50 Years

Eligibility

Inclusion Criteria:

• healthy, not currently taking any medications

Exclusion Criteria:

• unhealthy, taking medications

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Insulin Resistance

Locations

Country	Name	City	State
United States	University of Kansas Medical Center	Kansas City	Kansas

Sponsors (1)

Lead Sponsor	Collaborator
John Thyfault

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	insulin/glucose response to mixed meal ingestion		This study is cross-sectional. Primary and secondary measures will be assessed at a single timepoint.	No
Secondary	MSNA		This is a cross-sectional study. Primary and seconardy measures will be assessed at a single visit lasting 4-6 hours.	No
Secondary	Blood flow		This is a cross-sectional study. Primary and seconardy measures will be assessed at a single visit lasting 4-6 hours.	No