Effect of Growth Hormone on Insulin Signaling in Muscle Tissue

Insulin Resistance Clinical Trial

Official title:

The Effect of a Physiological Bolus of Growth Hormone (GH) on Insulin Signaling Pathways in Muscle Tissue From Healthy Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00477997
• Other study ID #: MM-GH-20070052
• Status: Completed
• Phase: N/A
• First received: May 23, 2007
• Last updated: April 20, 2009
• Start date: May 2007
• Est. completion date: August 2008

Study information

• Verified date: April 2009
• Source: University of Aarhus
• Contact: n/a
• Is FDA regulated: No
• Health authority: Denmark: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to examine the effects of a physiological bolus of growth hormone on insulin signaling pathways in muscle tissue in healthy lean men.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 8
• Est. completion date: August 2008
• Est. primary completion date: April 2008
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• Male

• Healthy

• Age between 18 and 30 years

• BMI = 26

Exclusion Criteria:

• Known present disease including diabetes mellitus

• BMI > 26

• Uses any medication

• Consumes > 21 units of alcohol per week

Study Design

Allocation: Randomized, Intervention Model: Factorial Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Insulin Resistance

Intervention

Device:
• Physiological Bolus of Growth Hormone
0,5 mg Norditropin

Locations

Country	Name	City	State
Denmark	Department M (endocrinology and diabetes)	Aarhus

Sponsors (2)

Lead Sponsor	Collaborator
University of Aarhus	Aarhus University Hospital

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	PI3-kinase activity i muscle tissue		2 hours	No
Secondary	Growth Hormone Signaling Proteins in Muscle Tissue and other Insulin Signaling Proteins in Muscle Tissue		2 hours	No