Insulin Resistance Clinical Trial
High protein diets are popular among Maori, especially on the East Coast of the North Island. The purpose of this study was to compare the metabolic effects of a moderate carbohydrate, high protein diet (MCHP) with a high carbohydrate-high fibre (HCHF) diet on insulin sensitivity in Maori at increased risk of developing diabetes and cardiovascular disease.
This was a 6-month pilot intervention study of self-identifying Maori participants in a
randomised control trial conducted in Dunedin and Invercargill. The study consisted of
three, two month phases and was conducted over a period of six months. Participants meeting
all the inclusion criteria were randomised into three groups: moderate carbohydrate-high
protein (MCHP), high carbohydrate-high fibre (HCHF) or a control group. Those randomised to
the experimental diets were recommended an energy intake based on their current BMI levels.
The aim of phase one was to achieve weight loss with weekly advice and support from the
research team. The aim of phase two was for weight maintenance with continued weekly advice
and support. Phase three consisted of a weight maintenance phase without support. Those in
the control group were instructed to follow their own self selected diet plan.
Outcome was determined by examining surrogate clinical endpoints. The clinical endpoints
included the following recorded measurements of anthropometric measurements, bioelectrical
impedance measurements, profile of mood state questionnaires, activity questionnaires, and
three day diet records were collected at 0, 2, 4 and 6 month periods. Biochemical measures
of lipid profile, fasting insulin and glucose, liver functions and uric acid levels were
also conducted.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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