Insulin Resistance Clinical Trial
Official title:
The Effect of Pharmacological Antilipolysis on the Metabolic Effects of Ghrelin
This study will investigate the non-growth-hormone-dependent metabolic effects of the hormone Ghrelin in growth hormone deficient subjects by examining the insulin tolerance as well as signal proteins in fat and muscle biopsies.
Ghrelin is a relatively 'new' hormone that is produced in the stomach and to a lesser extend
in the hypothalamus of the brain. The actions of ghrelin are diverse and includes stimulation
of the appetite center of the brain and the release of growth hormone. We have for the first
time shown that ghrelin also stimulates the metabolism of fatty acids and induces insulin
resistance in skeletal muscle. These effects have we confirmed in growth hormone deficient
subjects on a stabile substitution treatment with growth hormone and hydrocortisone. With
these subjects we can investigate the effects of ghrelin that are independent of growth
hormone. The present study is a continuation of these findings, as we wish to investigate
whether the insulin resistance effect of ghrelin is dependent of the concomitant metabolism
of fatty acids. This is possible by administration of the niacin acid antagonist Acipimox,
that blocks the fatty acid metabolism reversibly. We have applied this experimental principle
in other settings with success.
Knowledge of the effects of ghrelin in general can in shot-sight as well as in long-sight
have great importance for the understanding of growth disorders from overweight and type 2
diabetes to malnutrition and eating disorders.
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