Injury Clinical Trial
Official title:
Determination of Serum Vasopressin Levels and Correlation With Life-threatening Complications in Adults With Severe Hemorrhagic Shock.
The purpose of this study is to determine if vasopressin is used up by the body during traumatic shock (severe low blood pressure due to trauma).
For humans suffering trauma and severe hemorrhagic shock, no randomized controlled studies of
the effect of exogenous vasopressin use exist, although case reports have suggested it may be
of benefit. Even some moribund patients with "irreversible" shock survived severe hemorrhagic
shock after administration of vasopressin. This suggests that at least some patients
suffering severe trauma could benefit from AAVP administration. Recently, many clinicians and
notable research consortiums have suggested that AVP shows promise for human resuscitation
and have called for further human studies.
This is a prospective, single-center observational study designed to evaluate (1) whether
vasopressin is depleted in severe, but not minor, trauma; and (2) the degree to which
endogenous vasopressin levels predict the occurrence of ARDS, sepsis, or death. To test the
first hypothesis, serum vasopressin levels (continuous independent variable) will be assessed
at enrollment (time 0), 6, 12, 18, and 24 hours later, and correlated with the two levels of
trauma (categorical dependent variable). To test the second hypothesis, serum vasopressin
levels (now a continuous dependent variable) will be correlated with each of three
outcomes-death, ARDS, and sepsis.
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