Efficacy of Inhalation of Essential Oil on the Reduction of Inhalants Craving

Inhalants Craving Clinical Trial

Official title:

A Novel Approach of Substitution Therapy With Inhalation of Essential Oil for the Reduction of Inhalants Craving: A Double-blinded Randomized Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03296943
• Other study ID #: Graduate School Grant 2553
• Status: Completed
• Phase: Phase 3
• First received: September 24, 2017
• Last updated: September 26, 2017
• Start date: July 1, 2010
• Est. completion date: November 30, 2010

Study information

• Verified date: September 2017
• Source: Chulalongkorn University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Inhalants, which are neurotoxic central nervous system (CNS) suppressants, are frequently abused by young adults. Unlike other CNS depressants, including alcohol and opiates, no treatment is currently approved for inhalants dependence. In this report, a novel approach of substitution treatment for inhalants addiction was explored in a double-blinded, randomized, controlled crossover design to examine the effects of inhalation of essential oil (EO) and perfume (PF) on the reduction of cue-induced craving for inhalants in a cohort of thirty-four Thai males with inhalants dependence. The craving response was measured by the modified version of Penn Alcohol Craving Score for Inhalants (PACS-inhalants)

Recruitment information / eligibility

• Status: Completed
• Enrollment: 34
• Est. completion date: November 30, 2010
• Est. primary completion date: November 30, 2010
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Participants with ability to smell if they could correctly identify 3 out of 5 odors, namely fish sauce, lemon, onion, basil, and jasmine.

• Individuals with inducible picture-cues inhalant craving based on a 50% increase in craving score from baseline.

Exclusion Criteria:

• Individuals with a history of major psychiatric disorders, including psychotic and mood disorders

• Individuals with illicit substance dependence other than inhalants

• Individuals with allergic reactions to essential oil or perfume.

Related Conditions & MeSH terms

• Inhalants Craving

Intervention

Combination Product:
• Essential oil
To inhale the essential oil in an air-conditioned room, the container was flipped over to soak the roll-on cap that was then rolled-on circularly at the right mid-palm of the subject at 2 centimeter in diameter for 5 cycles.
• Perfume
To inhale the perfume in an air-conditioned room, the container was flipped over to soak the roll-on cap that was then rolled-on circularly at the right mid-palm of the subject at 2 centimeter in diameter for 5 cycles.

Behavioral:
• Cue-induced inhalants craving
Exposing individuals with a set of 12 pictures for one-minute (e.g., 5 second display per picture) every five minutes for three sets in total followed by another three sets of neutral/relaxing pictures of nature.

Locations

Country	Name	City	State
Thailand	Princess Mother National Institute on Drug Abuse Treatment	Pathum Thani

Sponsors (1)

Lead Sponsor	Collaborator
Chulalongkorn University

Country where clinical trial is conducted

Thailand, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Inhalants craving - PACS	Inhalants craving was measured by the Penn Alcohol Craving Scale for Inhalants (PACS-inhalants)	Daily for 3 days
Primary	Inhalants craving - VAS	Inhalants craving was measured by the Visual Analog Scale (VAS).	Daily for 3 days