Neo-nervegenesis in Inguinal Hernia Implant ProFlor

Status Completed

Clinical Trial Summary

The investigation is aimed at specifically demonstrating the ingrowth of newly formed nervous elements within a 3D dynamic responsive implant for inguinal hernia repair.

Clinical Trial Description

Biopsy specimen were excised at defined postoperative stages from patients who underwent hernia repair with the 3D prosthesis named ProFlor. Scope of the study was to determine the presence, quantity and quality of the neural ingrowth within the implant fabric. Histology revealed the presence of multiple nerve clusters that, starting from the early stage post-implantation, increased in number and degree of maturation. In the long term, neural elements assumed the typical aspect of normal nervous structures complete in all components. The development of highly specialized tissue such as nerves, together with other components of the abdominal wall already described in literature, seems to finalize a regenerative response. This kind of behavior, being the expected result from a device intended for the cure of inguinal hernia and its degenerative source, seems to be coherent with the pathogenesis of the disease. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04171102
Study type	Interventional
Source	University of Cagliari
Contact
Status	Completed
Phase	N/A
Start date	January 2013
Completion date	December 2016

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See also
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