Influenza Clinical Trial
Official title:
Detection of Influenza or SARS-CoV-2 Infection by IMS of Nasal Air Sampling
Multicapillary Ion mobility spectrometry of nasal air aspirates shall be investigated as screening tool for the detection of Influenza and SARS-CoV-2- infection.
Bacterial infections can be distinguished by analysis of the volatile organic compounds found
in breath.
In patients with suspected Influenza infection, nasal air samples will be taken and analyzed
by Multicapillary Ion mobility spectrometry (MCC IMS). Routinely all patients undergo
polymerase chain reaction (PCR) analysis of nasopharyngeal swabs for Influenza.
MCC IMS spectra will be compared between infected and non infected patients by cluster
analysis and discrimination analysis.
If the number of infected patients exceeds 50 an additional validation cohort will be
investigated sequentially otherwise validation will be performed during the Influenza
epidemic 2021.
Due to decreasing numbers of Influenza-A- Infections study was opened to also include
patients with suspected SARS-CoV-2 infections.
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