Influenza Clinical Trial
Official title:
The Effects of Attenuated Versus Inactivated Flu Vaccine in Twin Sets
This is one project of a larger ongoing study related to the immune system's response to the flu virus. This study is designed to investigate the immune response to the live attenuated influenza vaccine (LAIV) vs. the Inactivated Influenza Vaccine (IIV) in identical and fraternal twins.
This is a Phase I mechanistic study of licensed influenza vaccines. The study requires 10 monozygotic and 10 dizygotic sets of twins (40 total participants) to enroll. The duration of the study for an individual volunteer will be 4 weeks including screening and active participation. The study has a total of 3 visits. First visit: Procedures during this visit are: Informed consent process, enrollment, study assessments, 20 ml blood draw, and vaccination. Participants will be randomized to receive either LAIV or IIV. The time required to complete the first study visit will be about 30-40 minutes. 2nd (day 7 post vaccination) and 3rd (day 28 post vaccination ) visit: 20 ml blood will be obtained and the visit will take approximately 15 minutes. ;
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