Influenza Clinical Trial
Official title:
Vaccination and Infection: Indicators of Immunological Health and Responsiveness. Project 1: Plasmablast Trafficking and Antibody Response in Influenza Vaccination;
The purpose of this study is to investigate the responses to licensed trivalent, inactivated influenza vaccine (TIV) delivered by different routes: intramuscular (IM) and intradermal (ID) and to the live, attenuated influenza vaccine (LAIV) administered intranasally -- all given to generally healthy male and female adult volunteers.
The aim of this study is to compare the response to different formulations of licensed
influenza vaccines.
The type of seasonal influenza vaccination(s) received independently by volunteers in the
year(s) since their last study visit will not impact eligibility. Volunteers will be assigned
into one of three vaccine groups (intramuscular trivalent inactivated influenza vaccine
(TIV); live attenuated influenza vaccine (LAIV- given year 1 only) or intradermal TIV, based
on the type of study vaccine they received in 2010, 2011, 2012, or 2013. All participants
will receive a single dose of their assigned seasonal influenza vaccine. Volunteers will
complete 3 study visits at Day 0, Day 6-8 and Day 24-32.
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