Influenza Clinical Trial
Official title:
Novel Influenza A (H1N1) Surveillance Registry
The demographic characteristics, clinical features, course, and outcomes of severe H1N1 influenza infection requiring intensive care have not been defined rigorously and systematically. While the majority of patients in early reports of critically ill novel influenza A (H1N1) have respiratory involvement, up to 10-20% may present with non-respiratory organ failures, such as shock, seizures, or acute renal failure. The burden of disease and resource utilization of these patients remains largely unknown. The purpose of this surveillance registry is to characterize the demographics, clinical features, outcomes, and resource utilization of patients with H1N1 influenza infection who require intensive care.
| Status | Completed |
| Enrollment | 894 |
| Est. completion date | October 2010 |
| Est. primary completion date | April 2010 |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | N/A and older |
| Eligibility |
Inclusion Criteria: - Admission to an intensive care unit at a participating site with confirmed or suspected Novel H1N1 Influenza infection Exclusion Criteria: - Influenza-like illness due to non-influenza disease and negative testing for influenza |
Observational Model: Cohort
| Country | Name | City | State |
|---|---|---|---|
| United States | Alaska Native Medical Center | Anchorage | Alaska |
| United States | The Children's Hospital at Providence | Anchorage | Alaska |
| United States | Children's Healthcare of Atlanta at Egleston | Atlanta | Georgia |
| United States | Denver's Children Hospital | Aurora | Colorado |
| United States | Dell Children's Medical Center of Central Texas | Austin | Texas |
| United States | Johns Hopkins Bayview Medical Center | Baltimore | Maryland |
| United States | Johns Hopkins Children's Center | Baltimore | Maryland |
| United States | Johns Hopkins Hospital | Baltimore | Maryland |
| United States | Union Memorial Hospital | Baltimore | Maryland |
| United States | University of Maryland Shock Trauma Center | Baltimore | Maryland |
| United States | Earl K. Long Medical Center | Baton Rouge | Louisiana |
| United States | Our Lady of the Lake Regional Medical Center | Baton Rouge | Louisiana |
| United States | Boston Medical Center | Boston | Massachusetts |
| United States | Children's Hospital Boston | Boston | Massachusetts |
| United States | Children's Hospital of Montefiore | Bronx | New York |
| United States | University of North Carolina | Chapel Hill | North Carolina |
| United States | University of Virginia Children's Medical Center | Charlottesville | Virginia |
| United States | University of Virginia Medical Center | Charlottesville | Virginia |
| United States | Children's Memorial Hospital | Chicago | Illinois |
| United States | Cleveland Clinic Foundation | Cleveland | Ohio |
| United States | MetroHealth Medical Center | Cleveland | Ohio |
| United States | University Hospitals of Cleveland | Cleveland | Ohio |
| United States | Nationwide Children' Hospital | Columbus | Ohio |
| United States | University of Texas Southwestern Children's Medical Center | Dallas | Texas |
| United States | Centura St. Anthony Central Hospital | Denver | Colorado |
| United States | Denver Health Medical Center | Denver | Colorado |
| United States | Rose Medical Center | Denver | Colorado |
| United States | University of Colorado Health Sciences Center | Denver | Colorado |
| United States | Duke University Children's Hospital | Durham | North Carolina |
| United States | Duke University Medical Center | Durham | North Carolina |
| United States | Durham Regional Medical Center | Durham | North Carolina |
| United States | Providence Hospital | Everett | Washington |
| United States | University of San Francisco-Fresno Medical Center | Fresno | California |
| United States | Helen DeVos Children's Hospital | Grand Rapids | Michigan |
| United States | Moses Cone Health System | Greensboro | North Carolina |
| United States | Wesley Long Community Hospital | Greensboro | North Carolina |
| United States | Connecticut Children's Medical Center | Hartford | Connecticut |
| United States | Penn State Children's Hospital | Hershey | Pennsylvania |
| United States | Kapi'olani Center for Women and Children | Honolulu | Hawaii |
| United States | Baylor College of Medicine | Houston | Texas |
| United States | Texas Children's Hospital | Houston | Texas |
| United States | Mayo Clinic at Jacksonville | Jacksonville | Florida |
| United States | Darthmouth-Hitchcock Medical Center | Lebanon | New Hampshire |
| United States | Arkansas Children's Hiospital | Little Rock | Arkansas |
| United States | Children's Hospital Los Angeles | Los Angeles | California |
| United States | Kosair Children's Hospital | Louisville | Kentucky |
| United States | Holt'z Children's Hospital | Miami | Florida |
| United States | Miami Children's Hospital | Miami | Florida |
| United States | Children's Hospital of Wisconsin | Milwaukee | Wisconsin |
| United States | Children's Hospital and Clinics of Minnesota | Minneapolis | Minnesota |
| United States | University of Minnesota Children's Hospital | Minneapolis | Minnesota |
| United States | Intermountain Medical Center | Murray | Utah |
| United States | Monroe Carell Children's Hospital at Vanderbilt | Nashville | Tennessee |
| United States | Vanderbilt University Medical Center | Nashville | Tennessee |
| United States | Yale-New Haven Children's Hospital | New Haven | Connecticut |
| United States | Medical Center of Louisiana | New Orleans | Louisiana |
| United States | Ochsner Clinic Foundation | New Orleans | Louisiana |
| United States | Tulane University Health Sciences Center | New Orleans | Louisiana |
| United States | Children's Hospital and Research Center Oakland | Oakland | California |
| United States | McKay-Dee Hospital | Ogden | Utah |
| United States | Children's Hospital of Nebraska | Omaha | Nebraska |
| United States | Children's Hospital of Orange County | Orange | California |
| United States | The Children's Hospital of Philadelphia | Philadelphia | Pennsylvania |
| United States | Phoenix Children's Hospital | Phoenix | Arizona |
| United States | Doernbecher Children's Hospital | Portland | Oregon |
| United States | Utah Valley Regional Medical Center | Provo | Utah |
| United States | University of Rochester Medical Center | Rocherster | New York |
| United States | Rochester Methodist Hospital | Rochester | Minnesota |
| United States | St. Mary's Hospital, Mayo Clinic | Rochester | Minnesota |
| United States | University of California, Davis Medical Center | Sacramento | California |
| United States | LDS Hospital | Salt Lake City | Utah |
| United States | Primary Children's Medical Center | Salt Lake City | Utah |
| United States | UCSF Children's Medical Center | San Francisco | California |
| United States | UCSF-Moffitt Hospital | San Francisco | California |
| United States | UCSF-San Francisco General Hospital | San Francisco | California |
| United States | University of California, San Francisco (UCSF)-Moffitt Hospital | San Francisco | California |
| United States | Harborview Medical Center | Seattle | Washington |
| United States | Seattle Children's Hospital | Seattle | Washington |
| United States | University of Washington | Seattle | Washington |
| United States | Baystate Medical Center | Springfield | Massachusetts |
| United States | SSM Cardinal Glennon Children's Medical Center | St. Louis | Missouri |
| United States | St. Louis Children's Hospital | St. Louis | Missouri |
| United States | Children's Hospital at St. Francis | Tulsa | Oklahoma |
| United States | Children's National Medical Center | Washington | District of Columbia |
| United States | Washington Hospital Center | Washington DC | District of Columbia |
| United States | Wake Forest University Baptist Medical Center | Winston Salem | North Carolina |
| Lead Sponsor | Collaborator |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) |
United States,
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