Influenza A Virus/H5N1 Subtype Clinical Trial
Official title:
Host Genetic Susceptibility to Avian Influenza A/H5N1 in Vietnam, Thailand, Indonesia and Singapore
The identification and characterization of susceptibility loci for H5N1 infection in humans
could have profound implications. The detection of host genetic factors may shed light on
key pathogenic interactions between H5N1 and human cells, assisting in identifying the viral
characteristics determining pandemic potential. In addition, the identification and
verification of susceptibility loci would be followed by functional studies which might
point the way to new therapeutic and preventive options.
The objective of this study is to investigate if host genetic factors are associated with
susceptibility to influenza H5N1 illness
| Status | Completed |
| Enrollment | 500 |
| Est. completion date | October 2010 |
| Est. primary completion date | August 2010 |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | N/A and older |
| Eligibility |
Inclusion Criteria: - The individual had a clinically compatible illness (defined as respiratory symptoms and an abnormal chest x-ray or encephalitis), AND - Influenza A/H5 RNA identified in a clinical sample by reverse transcription-polymerase chain reaction [RT-PCR], OR - Influenza A/H5 cultured from a clinical sample, OR - High titres (1:80 or higher) of anti-H5 antibodies by microneutralization in convalescent samples of patients who had a compatible illness but no or negative RT-PCR, AND - The patient survived or if they died an archived biological specimen is available for potential DNA extraction, AND - Valid, written consent is obtained. - The biological parents and biological siblings of all the cases and any other family members linking two cases, AND - Valid, written consent is obtained. |
Observational Model: Family-Based, Time Perspective: Cross-Sectional
| Country | Name | City | State |
|---|---|---|---|
| Vietnam | Oxford University Clinical Research Unit | Hanoi |
| Lead Sponsor | Collaborator |
|---|---|
| South East Asia Infectious Disease Clinical Research Network | University of Oxford, Wellcome Trust |
Vietnam,
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