Inhibition of Sterile Inflammation by Digoxin

Status Completed

Clinical Trial Summary

To investigate the effect of digoxin on pyruvate kinase isoform 2 (PKM2) binding to pro-inflammatory loci and innate immune inflammatory responses in the peripheral blood in healthy subjects.

Clinical Trial Description

To investigate the effect of orally administered digoxin on innate immune inflammatory responses in the peripheral blood of healthy subjects. We hypothesize the reduction in innate immune inflammatory responses will be expected in the peripheral blood with the effect of oral digoxin. To investigation how human peripheral blood immune cells change their inflammatory responses after exposure to digoxin in vitro. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03559868
Study type	Interventional
Source	Yale University
Contact
Status	Completed
Phase	Phase 1
Start date	March 1, 2021
Completion date	May 5, 2023

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04496154` - Omega-3 to Reduce Diabetes Risk in Subjects With High Number of Particles That Carry "Bad Cholesterol" in the Blood	N/A
Not yet recruiting	`NCT06434701` - Severe COVID-19 Infection in Children Presenting to EDs in Israel and England	N/A
Enrolling by invitation	`NCT05020210` - Effect of Early Treatment With Sivelestat Sodium in ARDS Patients
Completed	`NCT04084301` - Impact of Cardiopulmonary Bypass Flow on Renal Oxygenation, Blood Flow and Tubular Injury	N/A
Completed	`NCT04597983` - Effect of 8-week Intake of 2S-hesperidin on Performance, Body Composition and Biochemicals Markers in Amateur Cyclists	N/A
Not yet recruiting	`NCT05990933` - Role of Adrenaline in in the Inflammatory Response in Diabetes	N/A
Not yet recruiting	`NCT06016023` - Evaluation of Macrophage Inflammatory Protein-1α as a Periodontal Disease Biomarker
Not yet recruiting	`NCT04608643` - Inflammatory Markers and Cbc Indices in Severely Malnourished Children
Recruiting	`NCT01934049` - Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty	Phase 4
Recruiting	`NCT01417923` - The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain	Phase 4
Terminated	`NCT01377441` - Effect of Intravenous Ibuprofen on Inflammatory Responses in Patients Undergoing Surgery With General Anesthesia.	Phase 4
Completed	`NCT01301079` - Evaluation of the Effect of Ketamine on Remifentanil-induced Hyperalgesia	Phase 3
Terminated	`NCT00578578` - Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels	Phase 4
Recruiting	`NCT04611334` - The Effects of HRV Biofeedback on Chronic Kidney Disease Patient.	N/A
Recruiting	`NCT03510702` - SCREENING OF EPIGENETIC BIOMARKERS (miRNAs) IN THE GINGIVAL SULCUS
Completed	`NCT03445234` - Blueberries, Bananas, Exercise Recovery	N/A
Not yet recruiting	`NCT06450704` - Cerebral and Anti-inflammatory Response Through Exercise - Mechanisms In Depressive Disorders	N/A
Not yet recruiting	`NCT05754294` - Electric Polarization of Red Blood Cells : A Cohort Study to Assess the Erythrocytes Membrane Integrity Through Charge Conservation, Following Cardiac Surgery.
Not yet recruiting	`NCT04386525` - Omega 3 and Ischemic Stroke; Fish Oil as an Option	Phase 4
Completed	`NCT04864600` - CANDLE - A Study of Acute Health Effects of Exposure to Particles Generated by Candles	N/A