Inflammatory Local Response During OLV: Protective vs Conventional Ventilation Strategy

Inflammatory Response Clinical Trial

Official title: Does a Protective One Lung Ventilation Strategy Reduce the Inflammatory Cytokine Local Response After Pulmonary Resection?

Status Completed

Clinical Trial Summary

This study evaluates the local cytokine inflammatory response during one lung ventilation in patients undergoing pulmonary lobectomy or wedge resection. We compare two different ventilation strategies: a conventional strategy with a protective strategy.

Clinical Trial Description

One-lung ventilation (OLV) is a ventilation procedure used for pulmonary resection often causing lung injury. International guidelines have recommended for years the use of conventional ventilation (CV) with high tidal volume (VT) (8-10 ml\kg).A body of recent evidences have shown that conventional ventilation can reduce systemic oxygenation, increase inflammatory products and cause lung tissue damage. In this study we compare the conventional strategy , consisted of Vt 10 mL/kg, with the protective strategy, consisted of Vt 5 mL/kg. Both Vt were based on predicted body weight (PBW). Broncho-alveolar lavages (BAL) are selectively performed in the dependent (ventilated) lung before and at the end of the OLV. The levels of pro-inflammatory (IL-1α, IL-1β, IL-6, IL-8, TNF) and anti-inflammatory (IL-2, IL-4, IL-10, INFγ) cytokines are evaluated. We also evaluate patients clinical outcomes in terms of incidence of postoperative respiratory complications and length of stay. ;

Related Conditions & MeSH terms

• Inflammatory Response
• Lung Injury
• Respiratory Complication
• Ventilator-Induced Lung Injury

• NCT number: NCT03056885
• Study type: Interventional
• Source: University of Roma La Sapienza
• Status: Completed
• Phase: N/A
• Start date: November 2, 2015
• Completion date: January 15, 2016