Inflammatory Bowel Diseases Clinical Trial
— MICIMaPOfficial title:
Prevalence of Periodontal Diseases in Inflammatory Bowel Diseases : a Pilot-study
NCT number | NCT04380922 |
Other study ID # | PO20062* |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | June 19, 2020 |
Est. completion date | June 10, 2022 |
Verified date | June 2022 |
Source | CHU de Reims |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Periodontal diseases are highly prevalent inflammatory diseases. It is now well known that they are correlated with numerous systemic diseases as : diabetes, chronic obstructive pulmonary disease, metabolic syndrome or rheumatoid arthritis. Recently, periodontal diseases have been correlated with inflammatory bowel diseases (IBD). IBD include two types, Crohn's disease and Ulcerative Colitis. It could be a significant risk factor for the pathogenesis of periodontal disease. These diseases present common features : a high prevalence worldwide, multifactorial pathogenies with common mechanisms. To date, no study has linked activity of IBD and periodontal diseases. The authors hypotheses that the prevalence of periodontal diseases could be increased in patient presenting an active IBD
Status | Completed |
Enrollment | 60 |
Est. completion date | June 10, 2022 |
Est. primary completion date | July 30, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility | Inclusion Criteria: Patients - consulting Gastroenterology departments in the university hospital of Reims or Amiens-Picardie for the management of Crohn's disease or Ulcerative colitis - signed informed consent form - affiliated to the French Social Security system Exclusion Criteria: Patients presenting: - a medical history likely to compromise protocol (psychiatric disorders, other inflammatory diseases, antibiotics, NSAIDs within the last 3 months) - Diabetes - Inflammatory rheumatism - Cancer or radiotherapy up to5 years before inclusion - X-ray therapy in the area of interest - Pregnancy or Breastfeeding - Eating disorders - Patients under legal protection, trusteeship or guardianship |
Country | Name | City | State |
---|---|---|---|
France | Chu Reims | Reims |
Lead Sponsor | Collaborator |
---|---|
CHU de Reims |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Prevalence of Periodontal Disease | Periodontal Disease will be diagnosed according to the new classification of periodontal diseases (Chicago, 2017) and defined by the decision-making algorithms (Tonetti and Sanz, 2019). Diagnosis will be based on Buccal or lingual Clinical attachment level (CAL), Recession (REC) and Periodontal Pocket Depths (PPD) measurement. | Day 0 | |
Secondary | Gingivitis | Gingivitis will be diagnosed according to the new classification of periodontal diseases (Chicago, 2017) and defined by the decision-making algorithms (Tonetti and Sanz, 2019). Bleeding On Probing (BOP) higher than 10% is considered as a Gingivitis | Day 0 | |
Secondary | Oral mucosa dermatological manifestations secondary to IBD | Defined by WHO criteria (2013) | Day 0 | |
Secondary | Oral Health Quality of Life | GOHAI validated in French for general population -Tubert-Jeanin et al., 2003) | Day 0 | |
Secondary | Oral treatment need | Evaluated by ICDAS (International Caries Detection and Assessment Score) (Ismaïl et al., 2007) | Day 0 |
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