Inflammatory Bowel Diseases Clinical Trial
— MINOTOROfficial title:
Genetic an Functional Studies of Patient With Inflammatory Bowel Disease
Verified date | November 2018 |
Source | University Hospital, Lille |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The objective of this study is to study the response of macrophages, isolated from patients with ulcerative colitis (Crohn's disease) or Crohn's disease (CD), to 6 candidate enterogenous and their derivatives, depending on the genotype for associated polymorphisms. to the development of IBD
Status | Completed |
Enrollment | 630 |
Est. completion date | April 10, 2017 |
Est. primary completion date | April 10, 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 6 Years and older |
Eligibility |
Inclusion Criteria: - patient with definite crohn's disease or ulcerative colitis Exclusion Criteria: - patient receiving anti-TNF therapy during 14 days before inclusion. |
Country | Name | City | State |
---|---|---|---|
France | CHRU, Hôpital Claude Huriez | Lille |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Lille |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Isolated macrophage response measured by PCR | identification of macrophage activation markers specific analysis of gene expression (by PCR in real time) and / or the production (ELISA) of proinflammatory molecules (IL-6, TNF-1 and IL-8), anti-inflammatory (IL-10) and immunomodulatory (IL4,PPAR -2, MOR) | Baseline: one session |
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