Inflammation Clinical Trial
Official title:
Evaluation of Inflammation Activity in Ulcerative Colitis by Probe-based Confocal Laser Endomicroscopy
The aim:1) To test the correlation of pCLE-obtained features with histological findings in UC; comparing the real-time conventional colonoscopy Baron score with CLE assessment. 2) To test the accuracy of the investigators previously proposed simplified four-grade classification system of crypt architecture in evaluating inflammation activity in UC by pCLE.
Patients with acute inflammatory infiltrates seen on histological assessment are more likely
to experience relapse than are those without infiltrates,studies suggest that severity of
inflammation is a risk factor for colorectal neoplasia in UC.
The assessment of inflammation activity by conventional colonoscopy is inaccurate in the
prediction of acute inflammation in some cases. Confocal laser endomicroscopy (CLE) allows
for real-time endoscopy and histological diagnosis of gastrointestinal diseases. In our
previous study, we confirmed a simplified four-grade classification system of crypt
architecture(Grade A :normal; Grade B: an irregular arrangement of colonic crypts with normal
size and shape, and enlarged spaces between crypts; Type C: an enlarged crypt opening and a
more irregular crypt arrangement than type B; Type D: crypt destruction and / or crypt
abscess) by eCLE in predicting acute inflammation, and found a good correlation with
histology. In this study, the investigators aimed to test the accuracy of the proposed tne
four-grade classification system in evaluating inflammation activity in UC by pCLE.
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