Effect of Early Enteral Nutrition on Serum Acetylcholine Level and Inflammation in Critically Ill Patients

Inflammation Clinical Trial

Official title:

Effect of Early Enteral Nutrition on Serum Acetylcholine Level and Inflammation in Critically Ill Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03612206
• Other study ID #: 2016NLYZDRC022
• Status: Completed
• Start date: January 1, 2017
• Est. completion date: April 1, 2018

Study information

• Verified date: July 2018
• Source: Nanjing PLA General Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Early enteral nutrition(EEN) is an important treatment for critical ill patients and attenuate systemic inflammation, but the mechanisms are not clear. Thus the investigator conducted this study to observe if EEN affects systemic inflammation though regulation of blood acetylcholine

Recruitment information / eligibility

• Status: Completed
• Enrollment: 113
• Est. completion date: April 1, 2018
• Est. primary completion date: March 1, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• initiating enteral nutrition within the first 24-48h after intensive care unit (ICU) admission

• age more than 18 years

• Acute Physiology and Chronic Health Evaluation II (APACHE II) score >8

Exclusion Criteria:

• not expected to survive 24 hours

• pregnancy

• any terminal stage disease

Related Conditions & MeSH terms

• Critical Illness
• Enteral Nutrition
• Inflammation

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Nanjing PLA General Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	28-day mortality	The number of survival and non-survival patients 28 days after inclusion	14 months
Primary	Intestinal barrier function within one week	The measurement of serum d-lactate was applied to evaluate the intestinal barrier function	14 months