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Effects of Transvenous Vagus Nerve Stimulation on Immune Response: a Pilot Study — NoSIRS  

Inflammation Clinical Trial

Official title:
Effects of Transvenous Vagus Nerve Stimulation on Immune Response: a Pilot Study

Clinical Trial Summary

The purpose of this study is to assess the effect of transvenous vagus nerve stimulation (tVNS) on the immune response.

In the human endotoxemia model, intravenously administered endotoxin (lipopolysaccharide [LPS]) elicits a systemic immune response with release of pro-inflammatory cytokines, such as TNF α. This trial will determine if an anti-inflammatory effect can be produced by acute VNS using a minimally invasive delivery method.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01944228
Study type Interventional
Source Medtronic Cardiac Rhythm Disease Management
Contact
Status Completed
Phase Phase 1
Start date August 2013
Completion date October 2013
View Details
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