Innate Immune Response in COPD

Inflammation Clinical Trial

Official title: Innate Immune Response in COPD

Status Completed

Clinical Trial Summary

The purpose of this study is to determine whether the response of the immune system to bacterial components differs between patients with severe COPD compared to those with less severe COPD.

Clinical Trial Description

The airways of COPD patients are often colonized with bacteria leading to increased airway inflammation. This study sought to determine whether systemic cytokine responses to microbial pathogen-associated molecular patterns (PAMPs) are increased among subjects with severe COPD.

In an observational cross-sectional study of COPD subjects, PAMP-induced cytokine responses were measured in whole blood ex vivo. We used PAMPs derived from microbial products recognized by TLR 1, 2, 4, 5, 6, 7, and 8. Patterns of cytokine response to PAMPs were assessed using hierarchical clustering. One-sided t-tests were used to compare PAMP-induced cytokine levels in blood from patients with and without severe COPD, and for subjects with and without chronic bronchitis. ;

Study Design

Observational Model: Cohort, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Bronchitis
• Bronchitis, Chronic
• Chronic Disease
• Immunity, Innate
• Inflammation
• Pulmonary Disease, Chronic Obstructive
• Toll-Like Receptors

• NCT number: NCT02637219
• Study type: Observational
• Source: VA Puget Sound Health Care System
• Status: Completed
• Phase: N/A
• Start date: March 2006
• Completion date: January 2008