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What To-be-discard Biomaterials From ART Cycles Can Tell us About the Treatment Cycle Outcome?

Infertility Clinical Trial

Official title:
What To-be-discard Biomaterials From ART Cycles Can Tell us About the Treatment Cycle Outcome?

Clinical Trial Summary

Various to-be-discard material from IVF treatment cycle will be collect and examined, aiming to identify potential reasons of successful outcome or cycle failure.

Clinical Trial Description

Usually around 2/3 of IVF material will be discarded at the end of each treatment cycle, including immature oocytes, abnormal fertilized zygotes, poor grading embryos, spent culture medium, etc. Next generation sequencing will be performed for DNA / RNA analysis including the length and the quantity, RNA-seq will be applied for transcriptome profiling, and protein profile will be investigated in a pool sample. By applying various diagnostic tools against those to-be-discard biomaterials, we aim to identify potential underlying reasons of indicating either for an IVF failure or a successful cycle, and try to develop a non-invasive testing method for embryo quality check; better detection of the embryo implantation potential and eventually further increase the IVF clinical outcome. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06021340
Study type Observational
Source Chinese University of Hong Kong
Contact Yiu Leung D Chan, DPhil
Phone (852) 3505 3199
Email drdcyl16@cuhk.edu.hk
Status Recruiting
Phase
Start date July 4, 2023
Completion date June 2027
View Details
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