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Is the AMH Intrafollicular Level a Predictor of the Ploidy Status of the Blastocyst?

Infertility Clinical Trial

Official title:
Is the AMH Intrafollicular Level a Predictor of the Ploidy Status of the Blastocyst? A Prospective Study

Clinical Trial Summary

To investigate, whether on the day of egg retrieval, after ovarian stimulation for ICSI (intracytoplasmic sperm injection), there is a correlation between the intrafollicular AMH (Anti-Müllerian hormone) levels and the ploidy status of the blastocyst.

Clinical Trial Description

In clinical practice, AMH is used as a diagnostic and/or prognostic marker in women in association with ovulation induction and in various pathophysiological conditions. This study looks to investigate if the hormonal environment that surrounds an oocyte has an impact on the ploidy status of the blastocyst. Nowadays, using NGS (Next Generation Sequencing) platform for analysis of 23 pairs of chromosomes for Preimplantation Genetic Testing on blastocysts, the ploidy status of the embryo is more adequately assessed. Furthermore, embryo culture to blastocyst will provide further information about embryo quality and possibilities of implantation. To have complete information between the serum hormones, follicular hormones, embryo development and ploidy will provide to clinicians, embryologist and patients further information on embryo selection and adequate ovarian stimulation protocols. The database will be exported from the clinical information manager, VRepro, to a table in excel format through a database-based query system. The exported data will be duly codified to protect the clinical and personal information of the participants. Prior to the statistical study, an exploratory data analysis will be carried out to review the quality of the information extracted. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05837325
Study type Observational
Source ART Fertility Clinics LLC
Contact Barbara Lawrenz, PhD
Phone 0097126528000
Email barbara.lawrenz@artfertilityclinics.com
Status Recruiting
Phase
Start date May 23, 2023
Completion date December 31, 2024
View Details
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